57070-77-6

Basic information

• Product Name: 2-bromo-5-methoxythiophene
• Synonyms: 2-bromo-5-methoxythiophene
• CAS NO: 57070-77-6
• Molecular Formula: C5H5BrOS
• Molecular Weight: 193.064
• Mol File: 57070-77-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 92-93 °C(Press: 19 Torr)
• Appearance: /
• Density: 1.623 g/cm3(Temp: 26 °C)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 2-bromo-5-methoxythiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-5-methoxythiophene(57070-77-6)
• EPA Substance Registry System: 2-bromo-5-methoxythiophene(57070-77-6)

Safety Data

• Hazardous Substances Data: 57070-77-6(Hazardous Substances Data)

Usage

General Description

2-bromo-5-methoxythiophene, also known as 2-bromo-5-methoxythiophene, is a chemical compound with the molecular formula C6H5BrOS. It is a brominated organic compound that contains a thiophene ring with a methoxy functional group attached to the 5th carbon. This chemical is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is also used as a precursor in the production of various materials and compounds. 2-bromo-5-methoxythiophene exhibits a range of chemical properties and reactivity, making it a versatile compound in various chemical processes.

Upstream product

• 16839-97-7 2-methoxythiophene 

Downstream Products

• 29212-22-4 5-methoxythiophene-2-carboxylic acid 
• 35087-46-8 2-methoxythiophene-5-carbaldehyde 
• 1431042-97-5 1-(5-((4-((5-methoxythiophen-2-yl)ethynyl)phenyl)ethynyl)thiophen-2-yl)ethanone 
• 1431043-00-3 2-methoxy-5-((4-((5-methylthiophen-2-yl)ethynyl)phenyl)ethynyl)thiophene 
• 1431042-95-3 ((4-((5-methoxythiophen-2-yl)ethynyl)phenyl)ethynyl)trimethylsilane 

Relevant articles and documents

ARYLAMIDES AND METHODS OF USE THEREOF

The present disclosure relates to heterocyclic compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis.

Synthesis, Nicotinic Acetylcholine Receptor Binding, and in Vitro and in Vivo Pharmacological Properties of 2′-Fluoro-(substituted thiophenyl)deschloroepibatidine Analogues

The synthesis, nAChR in vitro and in vivo pharmacological properties of 2′-fluoro-3′-(substituted thiophenyl)deschloroepibatidine analogues (5a-f, 6a-d, and 7a-c) are presented herein. All had subnanomolar affinity at α4β2*-nAChRs. Contrary to lead structure epibatidine, a potent nAChR agonist, all were potent α4β2- and α3β4-AChR antagonists in an in vitro functional assay. In vivo, the compounds were also nAChR antagonists with various degrees of agonist activity. Compounds 5e, 5f, 6a, 6c, 6d, and 7c had no agonist effects in the tail-flick, hot-plate, hypothermia, or spontaneous activity tests, whereas 5a-d, 7a and 7b did not have agonist activity in the tail-flick and hot-plate tests but, like varenicline, were agonists in the hypothermia and spontaneous activity tests. Compound 6b had agonist activity in all four in vivo tests. All the compounds were antagonists of nicotine-induced antinociception in the tail-flick test, and all except 5c, 5d, 5f, and 6b were antagonists of nicotine-induced antinociception in the hot-plate test. Compound 7c, which had a Ki = 0.86 nM in the binding assay similar potency at α4β2/α3β4 with selectivity relative to α7 nAChRs, had an AD50 value of 0.001 μg/kg in the tail-flick test with no agonist activity in the in vitro or in vivo test had one of the more interesting profiles.

Thiophene Systems. 13. The Synthesis of Novel Thienopyranones

The syntheses and spectral properties of novel dimethyl-substituted thieno-, - and pyranones are described.The uv spectra of the three systems are distinctly different as supported by HOMO/LUMO calculations. 5,6-Dihydro-5,5-dimethyl-7H-thienopyran-7-one (10) and 5,6-dihydro-6,6-dimethyl-4H-thienopyran-4-one (20) represent the first members of these thienopyranone ring systems.