57079-11-5

Basic information

• Product Name: CIS-5-AZA-4-OXO-OCT-2-EN-DIOIC ACID
• Synonyms: CIS-5-AZA-4-OXO-OCT-2-EN-DIOIC ACID;(2Z)-4-[(2-Carboxyethyl)aMino]-4-oxo-2-butenoic Acid;N-(2-Carboxyethyl)MaleaMic Acid;N-(3-carboxy-acryloyl)-β-alanine
• CAS NO: 57079-11-5
• Molecular Formula: C₇H₉NO₅
• Molecular Weight: 187.15
• Product Categories: Miscellaneous Reagents
• Mol File: 57079-11-5.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 548.1 °C at 760 mmHg
• Flash Point: 285.3 °C
• Appearance: white powder
• Density: 1.408 g/cm³
• Vapor Pressure: 1.83E-13mmHg at 25°C
• Refractive Index: 1.533
• Solubility: DMF, Methanol
• CAS DataBase Reference: CIS-5-AZA-4-OXO-OCT-2-EN-DIOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: CIS-5-AZA-4-OXO-OCT-2-EN-DIOIC ACID(57079-11-5)
• EPA Substance Registry System: CIS-5-AZA-4-OXO-OCT-2-EN-DIOIC ACID(57079-11-5)

Safety Data

• Hazardous Substances Data: 57079-11-5(Hazardous Substances Data)

Usage

Chemical Properties

White Powder

InChI:InChI=1/C7H9NO5/c9-5(1-2-6(10)11)8-4-3-7(12)13/h1-2H,3-4H2,(H,8,9)(H,10,11)(H,12,13)/b2-1-

Upstream product

• 108-31-6 maleic anhydride 
• 107-95-9 3-amino propanoic acid 
• 56-41-7 L-alanin 

Downstream Products

• 864354-31-4 3-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-N-methyl-N-phenyl-propionamide 
• 133860-61-4 3-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-propionic acid 4-nitro-phenyl ester 
• 5724-76-5 3-succinimidopropionic acid 

Relevant articles and documents

Tri-n-butyl(N-maleoyl-β-alaninato)tin

The Sn atom in [Sn(C4H9)3(C7H6NO 4)]n adopts a distorted trigonal-bipyramidal geometry, with three n-butyl groups defining the trigonal plane [mean Sn-C distance 2.145 (1) A] and the axial positions occupied by the O atoms of different carboxylate groups having significantly different Sn-O bond lengths [2.215 (5) and 2.424 (5) A]. The structure forms a polymeric chain of complex molecules linked via carboxylate moieties. ? Alternative name: catena-poly[[trimethyltin(IV)]-μ-[3-(2,5-dioxo-3-pyrazolin-1-yl)propionoato- O:O′]].

Comblike dendrimers containing Tn antigen modulate natural killing and induce the production of Tn specific antibodies

Comblike glycodendrimers were prepared by the chemoselective ligation of cysteine-modified glycopeptides (1-7) with a 3-maleimidopropionate-modified linear synthetic carrier (8). Glycodendrimers bearing mono-, di-, or tri-Tn clusters (9-11) were tested as inhibitors using plant and mammalian lectins. In the former group, the Codium fragile lectin showed moderate discrimination among 9, 10, and 11. In the latter group, A and B isoforms of rat NKR-P1 lectin strongly discriminated between 9 and 10. 10 caused a 4-fold increase in killing of the NK resistant tumor cell lines at concentrations as low as 10-8 M. Surprisingly, 11 interacted exclusively with the rat NKR-P1B isoform and inhibited efficiently natural killing in both rats and humans, even in the presence of the activating compounds 9 and 10. Dinitrophenol haptenization or influenza virus hemagglutinin T-cell epitope conjugation increased the immunogenicity of the parent compounds and resulted in the production of Tn specific antibodies.

Novel selective glucocorticoid receptor agonists (SEGRAs) with a covalent warhead for long-lasting inhibition

The synthesis and in vitro properties of six analogues of the selective glucocorticoid receptor (GR) agonist GSK866, bearing a warhead for covalent linkage to the glucocorticoid receptor, is described.

On the synthesis of N-maleoyl amino acids in aqueous media: Cautionary tales for the unwary traveller

The high cost or protracted syntheses associated with N-maleoyl amino acid derivatives coupled with a considerable demand from both the life and physical sciences has spurred the search for facile, low-cost routes to these compounds. Herein, we demonstrate that a recently published method purporting to deliver N-maleoyl amino acids by cyclization of maleamic acids in water, instead results in a hydrolysis product, namely the corresponding hemi-maleate salt. ARKAT USA, Inc.