57092-52-1

Usage

Uses

Used in Pharmaceutical Industry:
Z-PHE-PHE-PHE-OH is used as a hydrophobic modifier for dendritic peptide amphiphiles to enhance their solubility and stability in biological systems. The increased hydrophobic character can improve the interaction of these dendrimers with cell membranes and other biological targets, potentially leading to better drug delivery and therapeutic effects.
Used in Drug Delivery Systems:
In the field of drug delivery, Z-PHE-PHE-PHE-OH can be utilized as a component in the design of novel drug carriers. Its hydrophobic nature can facilitate the encapsulation and release of hydrophobic drugs, improving their bioavailability and targeting efficiency.
Used in Material Science:
Z-PHE-PHE-PHE-OH can also be employed in the development of new materials with specific properties, such as self-assembling systems or hydrogels, where its hydrophobic character can contribute to the formation of stable structures and control the release of encapsulated molecules.

Upstream product

• 1161-13-3 N-Cbz-L-Phe 
• 35661-40-6 N-Fmoc L-Phe 

Downstream Products

• 927190-63-4 (-)-N-benzyloxycarbonyl-L-phenylalanine-L-phenylalanine-L-phenylalanine thiophenyl ester 

Relevant academic research and scientific papers

Tuning the pH-triggered self-assembly of dendritic peptide amphiphiles using fluorinated side chains

We report the synthesis of a series of anionic dendritic peptide amphiphiles of increasing hydrophobic character. By establishing state diagrams we describe their pH and ionic strength triggered self-assembly into supramolecular nanorods in water and highlight the impact of hydrophobic shielding in the supramolecular polymerisation process. Via the incorporation of fluorinated peptide side chains the pH-triggered monomer to polymer transition at physiological ionic strength is shifted from pH 5.0 to pH 7.4. We thereby show that compensating attractive non-covalent interactions and hydrophobic effects with repulsive electrostatic forces, a concept we refer to as frustrated growth, is a sensitive tool in order to manipulate one-dimensional supramolecular polymerisation processes in water.

METHOD OF PREPARING A HYDROGEL

A method of preparing a hydrogel comprises : (i) reacting a first molecule comprising a carboxylic acid group and second molecule comprising an amine group or an alcohol group with a hydrolase enzyme to form a product comprising an amide bond or ester bond, wherein the hydrolase enzyme would normally catalyse the production of an amine or an alcohol from an amide or an ester under physiological conditions; and (ii) maintaining the product comprising an amide or ester bond under conditions suitable to allow hydrogel formation.