57093-77-3

Upstream product

• 589-92-4 1-methylcyclohexan-4-one 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 81831-45-0 Cyano-(1,4-dimethyl-cyclohexyl)-acetic acid ethyl ester 
• 71980-90-0 ethyl (1-cyano-4-methylcyclohex-1-yl)cyanoacetate 
• 114145-16-3 Ethyl α-cyano-4-methylcyclohexaneacetate 
• 196608-74-9 cis-1-(cyanomethyl)-4-methylcyclohexanecarbonitrile 
• 81831-44-9 1-Methoxycarbonylmethyl-4-methyl-cyclohexanecarboxylic acid methyl ester 
• 81831-43-8 1-Methoxycarbonylmethyl-4-methyl-cyclohexanecarboxylic acid methyl ester 
• 5433-06-7 1-carboxy-1-(4-methyl-cyclohexane) acetic acid 
• 54277-36-0 1,c-4-Dimethyl-r-1-cyclohexanessigsaeure-methylester 
• 54277-37-1 (1,4-Dimethyl-cyclohexyl)-acetic acid methyl ester 
• 57093-76-2 Methyl cis-4-methylcyclohexaneacetate 
• 57093-75-1 Methyl trans-4-methylcyclohexaneacetate 
• 6603-71-0 4-methylcyclohexyl acetic acid 
• 57093-62-6 cyano(4-methylcyclohexyl)acetic acid ethyl ester 
• 57093-63-7 cyano(4-methylcyclohexyl)acetic acid ethyl ester 

Relevant academic research and scientific papers

Microwave-assisted synthesis of 2-amino-thiophene-3-carboxylic derivatives under solvent-free conditions

Under microwave irradiation and solvent-free conditions, cyanoacetates (cyanoacetamides) react with ketones and sulphur in the presence of a small amount of morpholine to give 2-amino-thiophene-3-carboxylic derivatives. In particular, tetrahydro-benzo[b]thiophene-3-carboxylic acid N-aryl amides were synthesized in high yields of 84-95%. Copyright Taylor & Francis, Inc.

Identification of novel ligands for the Gabapentin binding site on the α2δ subunit of a calcium channel and their evaluation as anticonvulsant agents

As part of a program to investigate the structure-activity relationships of Gabapentin (Neurontin), a number of alkylated analogues were synthesized and evaluated in vitro for binding to the Gabapentin binding site located on the α2δ subunit of

Investigation into the preferred conformation of Gabapentin for interaction with its binding site on the α2δ subunit of a calcium channel

A series of conformationally restricted Gabapentin analogues has been synthesised and used to propose the preferred conformation of Gabapentin for it to bind to the α2δ subunit of a calcium channel.

Transition metal polyhydrides-catalyzed addition of activated nitriles to aldehydes and ketones via Knoevenagel condensation

Transition metal polyhydrides and dihydrogen complexes catalyze Knoevenagel addition of cyanoacetate to aldehydes and ketones under neutral and mild conditions, the adducts undergo dehydration to give substituted (E)-2-cyano-α,β-unsaturated esters exclusively.

Evaluation of various N-substituted azaspiranedione derivatives as potential antimicrobial agents

A series of N-substituted hydrazines were condensed with various spiro[4,5] and [5,5]anhydrides and the resultant N-substituted azaspiranediones were evaluated for antimicrobial activity. None displayed any significant activity in a variety of organisms tested.