57097-50-4Relevant academic research and scientific papers
Synthesis and radioprotective activity of mitochondria targeted dihydropyridines in vitro
Zhang, Yurui,Wang, Junying,Li, Yuanyuan,Wang, Feng,Yang, Fujun,Xu, Wenqing
, (2017/11/06)
The radiation-induced damage to mitochondrial oxidative respiratory chain could lead to generating of superoxide anions (O2-) and secondary reactive oxygen species (ROS), which are the major resources of continuous ROS production after radiation. Scavenging radiation-induced ROS effectively can help mitochondria to maintain their physiological function and relief cells from oxidative stress. Dihydropyridines (DHPs) are biomimetic hydrogen sources that could protect cells against radiation damage. In this study, we designed and synthetized three novel mitochondrial-targeted dihydropyridines (Mito-DHPs) that utilize the mitochondrial membrane potential to enter the organelle and scavenge ROS. MitoTracker confirmed Mito-DHPs accumulation in mitochondria, and the DCFH-DA assay demonstrated effective ROS scavenging activity. In addition, the γ-H2AX and comet assay demonstrated the ability of Mito-DHPs to protect against both radiation and ROS-induced DNA strand breaks. Furthermore, Mito-DHP1 proved to be non-toxic and displayed significant radioprotection activity (p 0.05) in vitro. Mito-DHPs are therefore promising antioxidants that could penetrate the membrane of mitochondria, scavenge excessive ROS, and protect cells against radiation-induced oxidative damage.
Synthesis and photoluminescent properties of novel 1,4-dihydropyridine derivatives
Liu, Manman,Li, Xiao,Zhang, Jian
, p. 880 - 883 (2015/01/30)
Six new 1,4-dihydropyridine derivatives were synthesized, the UV-vis absorption and photoluminescence of these compounds were also studied. All the compounds exhibited strong blue emissions. (λem:436-451nm). The results showed that the absorption maxima of the compounds vary from 332 to 345nm depending on the group bonded to dihydropyridines rings.
Synthesis and antioxidant activity of a series of novel 3-chalcone-substituted 1,4-dihydropyridine derivatives
Sun, Hao,Shang, Chengxiang,Jin, Longfei,Zhang, Jian
, p. 239 - 243 (2013/05/21)
New 3-chalcone-substituted 1,4-dihydropyridine (DHP) derivatives have been synthesized based on dimethyl or diethyl 2,6-dimethyl-4-phenyl-1,4-DHP-3,5- dicarboxylate. Their structures were confirmed by IR, 1H NMR, 13C NMR, and elemental analyses. The synthesized compounds were also screened for antioxidant properties.
Probing the energy efficiency of microwave heating and continuous-flow conventional heating as tools for organic chemistry
Devine, William G.,Leadbeater, Nicholas E.
experimental part, p. 127 - 143 (2011/07/07)
The energy efficiency of using microwave heating has been compared with batch and continuous-flow conventional heating for three reactions. As expected, as the scale is increased so the energy efficiency improves. In addition, the energy consumption is similar for both sealed and open vessel microwave processing. When using a conventionally heated continuous-flow approach, while the energy efficiency is significantly lower at small scales, as the scale in increased so the efficiency improves significantly. To probe the differences between conventional and microwave heating further, calculations based on heating water from room temperature to its boiling point in open-vessel batch mode are reported. While the conversion of electrical energy into heat by a heating mantle is significantly more efficient than conversion of electrical energy into microwave energy by the magnetron of a microwave unit, the fact that water can be heated so much faster using microwave irradiation as opposed to conventional heating means that, overall, the two methods are comparable in their energy consumption. ARKAT USA, Inc.
