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57102-95-1

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57102-95-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 57102-95-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,1,0 and 2 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 57102-95:
(7*5)+(6*7)+(5*1)+(4*0)+(3*2)+(2*9)+(1*5)=111
111 % 10 = 1
So 57102-95-1 is a valid CAS Registry Number.
InChI:InChI=1/C14H12N2O/c1-9(17)15-10-6-7-14-12(8-10)11-4-2-3-5-13(11)16-14/h2-8,16H,1H3,(H,15,17)

57102-95-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(9H-carbazol-3-yl)acetamide

1.2 Other means of identification

Product number -
Other names 3-Acetamidocarbazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:57102-95-1 SDS

57102-95-1Downstream Products

57102-95-1Relevant articles and documents

Conformationally restrained melatonin analogues: Synthesis, binding affinity for the melatonin receptor, evaluation of the biological activity, and molecular modeling study

Spadoni, Gilberto,Balsamini, Cesarino,Diamantini, Giuseppe,Di Giacomo, Barbara,Tarzia, Giorgio,Mor, Marco,Plazzi, Pier Vincenzo,Rivara, Silvia,Lucini, Valeria,Nonno, Romolo,Pannacci, Marilou,Fraschini, Franco,Stankov, Bojidar Michaylov

, p. 1990 - 2002 (2007/10/03)

The design, synthesis, and biological profile of several indole melatonin analogues with a conformationally restricted C3 amidoethane side chain are presented. Examination of the accessible conformations of the melatonin side chain led us to explore some of its fully or partially restricted analogues, 2-12, the binding affinity values of which were utilized to gain further insight on the melatonin binding site. Two pharmacophoric models have been devised for melatonin and the active compounds by conformational analysis and superimposition performed using the DISCO program. In these models, the melatonin side chain can adopt a gauche/anti conformation out of the indole plane. Another contribution of this study regards the observation of a possible binding point interaction around the C2 position of the indole, as suggested by the remarkably increased binding affinity observed in the C2-substituted analogues 6 and 9 and especially in the more rigid analogue 5. The biological activity and the efficacy of the new compounds were tested by measuring the inhibition of the forskolin-stimulated cAMP accumulation and the GTPγS index. Both analyses demonstrated that all of the compounds were full agonists with the exception of 4 and 9, which showed a slight reduction in efficacy and would seem to be partial agonists.

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