571200-97-0Relevant academic research and scientific papers
Human and rat monoamine oxidase-A are differentially inhibited by (S)-4-alkylthioamphetamine derivatives: Insights from molecular modeling studies
Fierro, Angelica,Osorio-Olivares, Mauricio,Cassels, Bruce K.,Edmondson, Dale E.,Sepulveda-Boza, Silvia,Reyes-Parada, Miguel
, p. 5198 - 5206 (2008/03/15)
Four enantiomerically pure (S)-4-alkylthioamphetamine derivatives were evaluated as monoamine oxidase (MAO) inhibitors using the human and rat isoforms of the enzyme. Molecular dockings were performed in order to gain insights regarding the binding mode o
A two-step method for the preparation of homochiral cathinones
Osorio-Olivares, Mauricio,Rezende, Marcos Caroli,Sepulveda-Boza, Silvia,Cassels, Bruce K.,Baggio, Ricardo F.,Munoz-Acevedo, Juan C.
, p. 1473 - 1477 (2007/10/03)
A simple method for the preparation of homochiral ring-substituted 1-aryl-2-aminopropanones 2 ('cathinones') is described, involving initial Friedel-Crafts acylation of aromatics with (S)- or (R)-N-trifluoroacetylalanyl chloride, followed by acid hydrolysis of the intermediate trifluoroacetamido intermediates 1, for which X-ray diffraction analysis confirmed the structures.
