407-23-8

Basic information

• Product Name: N-(trifluoroacetyl)alanine
• CAS NO: 407-23-8
• Molecular Formula: C₅H₆F₃NO₃
• Molecular Weight: 185.1012
• Mol File: 407-23-8.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 287.3°C at 760 mmHg
• Flash Point: 127.6°C
• Density: 1.441g/cm³
• Vapor Pressure: 0.000636mmHg at 25°C
• Refractive Index: 1.395
• CAS DataBase Reference: N-(trifluoroacetyl)alanine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(trifluoroacetyl)alanine(407-23-8)
• EPA Substance Registry System: N-(trifluoroacetyl)alanine(407-23-8)

Safety Data

• Hazardous Substances Data: 407-23-8(Hazardous Substances Data)

Upstream product

• 56-41-7 L-alanin 
• 500-73-2 phenyl trifluoroacetate 
• 407-25-0 trifluoroacetic anhydride 
• 354-32-5 trifluoracetyl chloride 
• 431-47-0 trifluoroacetic acid-methyl ester 
• 383-63-1 ethyl trifluoroacetate, 
• 777-33-3 N-trifluoroacetyl-L-aspartic acid anhydride 
• 71-23-8 propan-1-ol 
• 6003-05-0 L-alanine hydrochloride 

Downstream Products

• 1479-31-8 N-trifluoroacetyl-L-alanine anilide 
• 62840-99-7 (S)-2--1-phenylpropane 
• 329-36-2 N-trifluoroacetyl-L-alanyl-L-phenylalanine methyl ester 
• 234108-30-6 (2S,2S)-N-(2,4-dimethoxybenzyl)-N-(2-hydroxypropyl)-2-(2,2,2-trifluoroacetylamino)propionamide 
• 677277-64-4 S-(-)-2-[N-(trifluoroacetyl)amino]-1-(2,5-dimethoxy-4-bromophenyl)-1-propanone 
• 571201-00-8 (S)-2-trifluoroacetamido-1-(4-ethylthiophenyl)-1-propanone 
• 571200-97-0 (S)-2-trifluoroacetamido-1-(4-methylthiophenyl)-1-propanone 
• 571200-81-2 (S)-2-trifluoroacetamido-1-(4-methylphenyl)-1-propanone 
• 97589-52-1 N-[(1S)-1-methyl-2-oxo-2-phenylethyl]-2,2,2-trifluoroacetamide 
• 1998-98-7 N-Trifluoracetyl-L-alanin-thiophenylester 

Relevant articles and documents

Active Controlled and Tunable Coacervation Using Side-Chain Functional α-Helical Homopolypeptides

We report the development of new side-chain amino acid-functionalized α-helical homopolypeptides that reversibly form coacervate phases in aqueous media. The designed multifunctional nature of the side-chains was found to provide a means to actively control coacervation via mild, biomimetic redox chemistry as well as allow response to physiologically relevant environmental changes in pH, temperature, and counterions. These homopolypeptides were found to possess properties that mimic many of those observed in natural coacervate forming intrinsically disordered proteins. Despite ordered α-helical conformations that are thought to disfavor coacervation, molecular dynamics simulations of a polypeptide model revealed a high degree of side-chain conformational disorder and hydration around the ordered backbone, which may explain the ability of these polypeptides to form coacervates. Overall, the modular design, uniform nature, and ordered chain conformations of these polypeptides were found to provide a well-defined platform for deconvolution of molecular elements that influence biopolymer coacervation and tuning of coacervate properties for downstream applications.

The: Ortho -substituent on 2,4-bis(trifluoromethyl)phenylboronic acid catalyzed dehydrative condensation between carboxylic acids and amines

2,4-Bis(trifluoromethyl)phenylboronic acid is a highly effective catalyst for dehydrative amidation between carboxylic acids and amines. Mechanistic studies suggest that a 2:2 mixed anhydride is expected to be the only active species, and the ortho-substituent of boronic acid plays a key role in preventing the coordination of amines to the boron atom of the active species, thus accelerating the amidation. This catalyst works for α-dipeptide synthesis.

Direct, visible light-sensitized benzylic C[sbnd]H fluorination of peptides using dibenzosuberenone: selectivity for phenylalanine-like residues

A visible light-sensitized benzylic sp3C[sbnd]H fluorination protocol using dibenzosuberenone (5?mol?%) and Selectfluoris optimized for the direct functionalization of phenylalanine-like residues in short chain peptides. Amino acids, dipeptides, and tripeptides undergo benzylic fluorination with remarkable regioselectivity in the presence of protected basic, acidic, and nonpolar side chains (including those with tertiary sites). Additionally, protecting group compatibility, a gram scale application, and competition experiments were explored.