5713-57-5

Basic information

• Product Name: 2-(4-methylphenyl)sulfonylthiophene
• Synonyms: 2-(4-methylphenyl)sulfonylthiophene
• CAS NO: 5713-57-5
• Molecular Formula: C₁₁H₁₀O₂S₂
• Molecular Weight: 238.33
• Mol File: 5713-57-5.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 398.4°Cat760mmHg
• Flash Point: 194.7°C
• Appearance: /
• Density: 1.298g/cm³
• Vapor Pressure: 3.41E-06mmHg at 25°C
• Refractive Index: 1.602
• CAS DataBase Reference: 2-(4-methylphenyl)sulfonylthiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methylphenyl)sulfonylthiophene(5713-57-5)
• EPA Substance Registry System: 2-(4-methylphenyl)sulfonylthiophene(5713-57-5)

Safety Data

• Hazardous Substances Data: 5713-57-5(Hazardous Substances Data)

Usage

Molecular structure

Consists of a thiophene ring with a sulfonyl group and a 4-methylphenyl group attached to it.

Stability

The sulfonyl group imparts good stability to the compound.

Reactivity

The sulfonyl group enhances the reactivity of the compound.

Use as intermediate

It is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals.

Specific properties

Its specific properties and applications make it an important building block in the production of various chemicals and materials.

InChI:InChI=1/C11H10O2S2/c1-9-4-6-10(7-5-9)15(12,13)11-3-2-8-14-11/h2-8H,1H3

Upstream product

• 3437-95-4 2-Iodothiophene 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 6165-68-0 thiophene boronic acid 
• 98-59-9 p-toluenesulfonyl chloride 
• 188290-36-0 thiophene 
• 52260-00-1 2-thiophene sulfonyl hydrazine 
• 36651-88-4 N-(4-methylphenylazo)pyrrolidine 
• 124066-73-5 tris(thiophenyl-2-yl)bismuth 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 1026668-29-0 bis(2-thiophenyl)iodonium tosylate 
• 96-43-5 2-thienyl chloride 
• 58042-63-0 2-(p-tolylsulfanyl)thiophene 
• 455-16-3 p-toluenesulfonyl fluoride 

Relevant articles and documents

Sulfonylation of Bismuth Reagents with Sulfinates or SO2through BiIII/BiV Intermediates

Studies to explore the catalytic activities of main-group elements are attractive. We report here our study of sulfonylation of bismuth reagents with sulfinates or SO2 surrogates. Under oxidative conditions, triarylbismuthines and sulfinates were transformed into diaryl sulfones. A transition-metal-like two-electron redox process at the Bi center was achieved in this reaction. Sulfur dioxide generated in situ can also replace sulfinates to deliver the corresponding symmetric diaryl sulfones. A rational mechanism for this reaction was also proposed that involves a Bi(III)-Bi(V) manifold.

A practical synthesis of aryl sulfones via cross-coupling of sulfonyl hydrazides with aryltriazenes using copper/ionic liquid combination

A new and efficient approach adopting copper-catalyzed cross-coupling of sulfonyl hydrazides with aryltriazenes has been developed to synthesize aryl sulfones using Br?nsted acidic ionic liquid as promoter under ambient conditions. The process employs stable and easy to handle reacting partners, and is endowed with broad substrate scope.

Rapid transformation of sulfinate salts into sulfonates promoted by a hypervalent iodine(III) reagent

An alternative method for forming sulfonates through hypervalent iodine(III) reagent-mediated oxidation of sodium sulfinates has been developed. This transformation involves trapping reactive sulfonium species using alcohols. With additional optimization of the reaction conditions, the method appears extendable to other nucleophiles such as electron-rich aromatic systems or cyclic ethers through a ring opening pathway.