57133-55-8

Upstream product

• 134641-70-6 ((6S,7R)-7-Nitro-1,4-dioxa-spiro[4.5]dec-6-yl)-phenylsulfanyl-acetic acid ethyl ester 
• 24731-17-7 ethyl 2-(2-oxocyclohexyl)acetate 
• 107-21-1 ethylene glycol 
• 104-15-4 toluene-4-sulfonic acid 
• 1125-99-1 1-(1-Cyclohexen-1-yl)pyrrolidine 
• 103724-93-2 3-nitrocyclohex-2-en-1-one ethylene acetal 

Downstream Products

• 770713-92-3 benzyl-[2-(1,4-dioxaspiro[4.5]dec-6-yl)ethyl]amine 
• 770714-08-4 [2-(1,4-dioxaspiro[4.5]dec-6-yl)ethyl](1-phenylethyl)amine 
• 770713-90-1 N-benzyl-2-(1,4-dioxaspiro[4.5]dec-6-yl)acetamide 
• 770714-07-3 2-(1,4-dioxaspiro[4.5]dec-6-yl)-N-(1-phenylethyl)acetamide 
• 10198-33-1 (+/-)-2-(2'-acetoxyethyl)cyclohexanone 
• 809233-36-1 [2-(1,4-dioxaspiro[4.5]dec-6-yl)ethyl]-[3-(2-iodo-4,5-dimethoxyphenyl)propyl]amine 
• 809233-34-9 [2-(1,4-dioxaspiro[4.5]dec-6-yl)ethyl]-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]amine 
• 809233-38-3 1-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]octahydroindole-7a-carbonitrile 
• 809233-33-8 [2-(1,4-dioxaspiro[4.5]dec-6-yl)ethyl]-[2-(2-iodophenyl)ethyl]amine 
• 809233-18-9 [2-(2-bromophenyl)ethyl]-[2-(1,4-dioxaspiro[4.5]dec-6-yl)ethyl]amine 

Relevant academic research and scientific papers

N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives

The invention provides the compounds represented by the formula (I) in which, R stands for a dihydroxy-substituted C1-C6 alkyl group, and Cy stands for an optionally substituted C6-C10 bi- or tri-cyclic aliphati

Angularly substituted octahydroindoles, decahydroquinolines, octahydropyrindines, and octahydrocyclopenta[b]pyrroles by Bruylants reaction

The easily available cycloalkanoyl acetic- and propionic acid esters are transformed to the corresponding amines by standard procedures. These in turn provided an efficient access to cyclic α-aminonitriles, which were reacted with a series of Grignard reagents yielding stereoselectively the cis-configured title compounds; the scope and limitation of this route were investigated. The stereochemical assignment was achieved by X-ray crystallography and NMR spectroscopy. Springer-Verlag 2004.

Process for the production of lipoic acid

PCT No. PCT/GB96/01278 Sec. 371 Date May 12, 1999 Sec. 102(e) Date May 12, 1999 PCT Filed May 30, 1996 PCT Pub. No. WO96/38437 PCT Pub. Date Dec. 5, 1996A process for the preparation of lipolic acid (thioctic acid), or a derivative thereof, is one in whic

The synthesis of (R)-(+)-lipoic acid using a monooxygenase-catalysed biotransformation as the key step

2-(2-Acetoxyethyl)cyclohexanone (4) was converted into the lactone (-)-(5) regio- and enantioselectively using 2-oxo-Δ3-4,5,5-trimethylcyclopentenyl acetyl-CoA monooxygenase, an NADPH-dependent Baeyer-Villiger monooxygenase from camphor grown Pseudomonas putida NCIMB 10007. The lactone (-)-(5) was converted into (R)-(+)-lipoic acid in six steps. In contrast cyclopentanone monooxygenase, an NADPH-dependent Baeyer-Villiger monooxygenase from cyclopentanol-grown Pseudomonas sp. NCIMB 9872 selectively oxidized the (S)-enantiomer of the ketone (4) giving better access to optically enriched, naturally occurring lipoic acid.

Reaction of 2-nitro and 3-nitro-2-cyclohexenone acetals: Preparation of useful intermediates

Preparation of 2-nitro-2-cyclohexenone acetal 31 starting from 2-nitrocyclohexanone acetal 29 has been reported for the first time. This compound as well as 3-nitro-2-cyclohexenone acetal 1, whose synthesis has been reported by us earlier, react with a variety of nucleophiles to form highly functionalised intermediates. One of them viz. 21 is converted into a bicyclic α-methylene-γ-lactone 24 using radical chemistry.