770714-07-3Relevant academic research and scientific papers
Angularly substituted octahydroindoles, decahydroquinolines, octahydropyrindines, and octahydrocyclopenta[b]pyrroles by Bruylants reaction
Reimann, Eberhard,Ettmayr, Christian,Polborn, Kurt
, p. 557 - 579 (2007/10/03)
The easily available cycloalkanoyl acetic- and propionic acid esters are transformed to the corresponding amines by standard procedures. These in turn provided an efficient access to cyclic α-aminonitriles, which were reacted with a series of Grignard reagents yielding stereoselectively the cis-configured title compounds; the scope and limitation of this route were investigated. The stereochemical assignment was achieved by X-ray crystallography and NMR spectroscopy. Springer-Verlag 2004.
