57135-17-8Relevant academic research and scientific papers
Synthesis, biological evaluation, and structure-activity relationships of N -benzoyl-2-hydroxybenzamides as agents active against P. falciparum (K1 strain), trypanosomes, and leishmania
Stec, Jozef,Huang, Qingqing,Pieroni, Marco,Kaiser, Marcel,Fomovska, Alina,Mui, Ernest,Witola, William H.,Bettis, Samuel,McLeod, Rima,Brun, Reto,Kozikowski, Alan P.
experimental part, p. 3088 - 3100 (2012/06/01)
In our efforts to identify novel chemical scaffolds for the development of new antiprotozoal drugs, a compound library was screened against Toxoplasma gondii tachyzoites with activity discovered for N-(4-ethylbenzoyl)-2- hydroxybenzamide 1a against T. gon
Synthesis of Some 2-Aryl-1,2,4-triazolobenzoxazin-5-ones as Tools To Define the Essential Pharmacophoric Descriptors of a Benzodiazepine Receptor Ligand
Catarzi, Daniela,Cecchi, Lucia,Colotta, Vittoria,Filacchioni, Guido,Varano, Flavia,et al.
, p. 2196 - 2201 (2007/10/02)
The synthesis and benzodiazepine receptor (BZR) affinity of some 1,2,4-triazolo-benzoxazin-5-ones, 2-22, are reported.Compounds 2-22 are devoid of the proton donor group, which according to a BZR schematic model was one of the pharmacophoric descriptors for receptor-ligand interaction.The binding data show that 2-(2-fluorophenyl)-9-chloro-1,2,4-triazolobenzoxazin-5-one (12) and some other compounds display nanomolar BZR affinity, indicating that the hydrogen donor group is not essential for the anchoring of 6,6,5-tricyclic systems to the BZR but only affects the potency of a ligand.
