57145-23-0

Upstream product

• 860763-57-1 2,2-dimethyl-1-phenyl-3-p-tolyl-propan-1-one 
• 547-63-7 Methyl isobutyrate 
• 104-81-4 4-Methylbenzyl bromide 
• 624-31-7 4-tolyl iodide 
• 75-98-9 Trimethylacetic acid 

Downstream Products

• 71617-15-7 2-methyl-1-(4-tolyl)propan-2-yl acetate 
• 1215018-73-7 2,2-dimethyl-N-(quinolin-8-yl)-3-(p-tolyl)propanamide 
• 1623774-86-6 N-(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)-2,2-dimethyl-3-(p-tolyl)propanamide 
• 1623774-96-8 N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-2-(3-methoxybenzyl)-2-methyl-3-(ptolyl)propanamide 
• 1623774-95-7 N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-2-(4-fluorobenzyl)-2-methyl-3-(ptolyl)propanamide 
• 857772-05-5 C₁₂H₁₅ClO 

Relevant academic research and scientific papers

Hypervalent Iodine(III)-Mediated Decarboxylative Ritter-Type Amination Leading to the Production of α-Tertiary Amine Derivatives

α-Tertiary amines (ATAs) are attractive structural motifs that are frequently found in biologically active molecules. Therefore, the development of an efficient method for the synthesis of ATAs represents an important research topic in the field of medicinal chemistry as well as organic chemistry. Although the Ritter reaction is a reliable approach for preparing α-tertiary amine derivatives via intermolecular amination reactions, the typical methods suffer from disadvantages such as harsh reaction conditions and the use of strong acids. Because of this, it has been of limited use in the synthesis of ATAs. We report here on the decarboxylative Ritter-type amination of carboxylic acids bearing an α-quaternary carbon center using a combination of PhI(OAc)2 and molecular iodine (I2) to produce the corresponding α-tertiary amine derivatives. This reaction proceeded at ambient temperature on the benchtop with a fluorescent light. Mechanistic investigations suggest that the reaction proceeds via the formation of an alkyl iodide and a higher oxidation state iodine(III) species as key intermediates. Similarly, a stepwise protocol for the Ritter-type amination of alcohols via the formation of oxalic acid monoalkyl esters was also achieved. The present methods represent a useful tool for the synthesis of ATAs that are difficult to prepare by conventional methods.

Pd-Catalyzed β-C(sp3)?H Arylation of Propionic Acid and Related Aliphatic Acids

A generally applicable Pd-catalyzed protocol for the β-C(sp3)?H arylation of propionic acid and related α-branched aliphatic acids is reported. Enabled by the use of N-acetyl-β-alanine as ligand our protocol delivers a broad range of arylation products. Notably, the highly challenging substrate, propionic acid, which lacks any acceleration through the Thorpe–Ingold effect, can be employed as substrate with synthetically useful yields. Furthermore, the scalability and synthetic applicability of the protocol are demonstrated.

Indaneacetic acid derivatives

This invention provides new compounds of formula I, STR1 wherein R1 is lower alkyl, R2 is hydrogen or lower alkyl, R3 is hydrogen or lower alkyl, R4 is hydrogen or lower alkyl, R5 is hydrogen, chlorine or lower alkyl, and each of R6 and R7 is hydrogen, or, when R5 is hydrogen, R6 may also be chlorine or lower alkyl, and R7 chlorine or lower alkyl, Useful as anti-phlogistic and anti-arthritic agents.