57152-12-2Relevant academic research and scientific papers
Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs
Guandalini,Martini,Di Cesare Mannelli,Dei,Manetti,Scapecchi,Teodori,Ghelardini,Romanelli
supporting information; experimental part, p. 1936 - 1939 (2012/04/04)
A series of analogs of DM235 and MN19, characterized by rings with different size, have been prepared and evaluated for their nootropic activity in the mouse passive-avoidance test. It was found that the optimal ring size for the analogs of DM235, showing endocyclic both amidic groups, is 6 or 7 atoms. For the compounds structurally related to MN19, carrying an exocyclic amide group, the piperidine ring is the moiety which gives the most interesting compounds.
Method for controlling emesis with N-(1-substituted-3-pyrrolidinyl)benzamides and thiobenzamides
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, (2008/06/13)
A method is disclosed for controlling emesis utilizing N-(1-substituted-3-pyrrolidinyl)benzamides and thiobenzamides of the formula: SPC1 Wherein R is cycloalkyl, phenyl and phenyllower-alkyl; R1 is hydrogen, lower alkyl of 1 to 8 carbon atoms
