57178-93-5Relevant academic research and scientific papers
N2H4-H2O Enabled Umpolung Cyclization of o-Nitro Chalcones for the Construction of Quinoline N-Oxides
Zhang, Guan,Yang, Kai,Wang, Shihui,Feng, Qiang,Song, Qiuling
supporting information, p. 595 - 600 (2021/02/03)
Umpolung is a unique strategy which converts the property of an atom into the opposite one. An efficient and general method for the construction of quinoline N-oxides via umpolung of carbonyl groups was developed from ortho-nitro chalcones and hydrazine i
One-Pot Synthesis of Functionalized Carbazoles via a CAN-Catalyzed Multicomponent Process Comprising a C-H Activation Step
González, Juan F.,Rocchi, Damiano,Tejero, Tomás,Merino, Pedro,Menéndez, J. Carlos
supporting information, p. 7492 - 7502 (2017/07/26)
The microwave-promoted three-component reaction between o-nitrochalcones, primary amines and β-dicarbonyl compounds in the presence of Ce(IV) ammonium nitrate constitutes the first example of a multicomponent carbazole synthesis. This reaction furnishes highly substituted and functionalized carbazole derivatives via a double annulation process that generates two C-C and two C-N bonds, with water as the only side product. Mechanistically, this transformation has some unusual features that include an intramolecular coupled hydrogenation-dehydrogenation process, the functionalization of a C-H group by direct attack onto a nitrogen function and a CAN-catalyzed reduction via hydride transfer from ethanol. The mechanisms of these reactions were studied with the aid of computational techniques.
Redox-Neutral Access to Sultams from 2-Nitrochalcones and Sulfur with Complete Atom Economy
Nguyen, Thanh Binh,Retailleau, Pascal
supporting information, p. 3879 - 3882 (2017/07/26)
A catalyst-free, redox-neutral, and completely atom-economical synthesis of sultams by simply heating 2-nitrochalcones with elemental sulfur in 3-picoline or N-methylmorpholine is described. The S-N, C-S, and S=O bonds of the sulfonamide are efficiently f
Montmorillonite clay-promoted, solvent-free cross-aldol condensations under focused microwave irradiation
Rocchi, Damiano,Gonzalez, Juan F.,Menendez, J. Carlos
supporting information, p. 7317 - 7326 (2014/07/08)
An environmentally benign, clean and general protocol was developed for the synthesis of aryl and heteroaryl trans-chalcones. This method involved solvent-free reaction conditions under microwave irradiation in the presence of a clay-based catalyst, and afforded the target compounds in good yields and short reaction times. Furthermore, the same conditions allowed the synthesis of symmetrical, diarylmethylene-a,a-unsaturated ketones from aromatic aldehydes and ketones.
Synthesis of 2-Acyl- and 2-Benzoylindoles
Mali, Raghao S.,Tilve, Santosh G.,Desai, Vidya G.
, p. 150 - 158 (2007/10/03)
2-Nitrobenzaldehydes (3a-c) on reaction with phosphoranes (4a and 4b), and triphenyl phosphine in refluxing diphenylether provide 2-acylindoles (6a-c) and 2-benzoylindoles (6d-f). Alternatively 2-nitrobenzaldehydes (3a-c) on reaction with phosphoranes (4a and 4b) give nitroketones (5a-f) which on refluxing with triphenyl phosphine in refluxing diphenyl ether furnish 2-acyl- and 2-benzoylindoles (6a-f).
Preparation, reduction chimique et electrochimique d'α-nitrostyrylcetones - synthese d'heterocycles azotes
Marcot, Bernard,Rabaron, Alain,Viel, Claude,Bellec, Christian,Deswarte, Stephane,Maitte, Pierre
, p. 1224 - 1234 (2007/10/02)
Nitration of styryl ketones with nitrogen peroxide leads to the corresponding α-nitroethylenic ketones in good yield.However, the presence of methoxy groups involves a nitration on the aromatic nucleus.LiAlH4 reduction of α-nitrostyrylketones yields the c
