57183-26-3

Upstream product

• 57183-08-1 (5-(benzyloxy)-4,6-dimethylpyridin-3-yl)methanol 
• 100-44-7 benzyl chloride 

Downstream Products

• 757957-67-8 [(5-Benzyloxy-4,6-dimethyl-pyridin-3-yl)-hydroxy-methyl]-phosphonic acid diethyl ester 

Relevant academic research and scientific papers

Pyridoxine-derived bicyclic amido-, ureido-, and carbamato-pyridinols: Synthesis and antiangiogenic activities

We recently developed an efficient and practical synthesis for a novel series of pyridoxine-derived 6-amido-2,4,5-trimethylpyridin-3-ols and found that this novel scaffold has outstanding activity to inhibit angiogenesis measured by the quantitative chick embryo chorioallantoic membrane (CAM) assay. As an effort to extend the scope of the amidopyridinol scaffold, we here report the synthesis and antiangiogenic activities of a series of bicyclic versions of the amidopyridinol including five- and six-membered cyclic amide-, cyclic urea-, and cyclic carbamate-fused pyridinols. The six membered bicyclic derivatives were prepared by the reported procedures, and the five-membered ring-fused ones were synthesized by new synthetic methods developed in this study. CAM assays showed that both six- and five-membered lactam-fused pyridinols have activities comparable to sunitinib malate, the positive control, in inhibition of vascular endothelial growth factor-induced angiogenesis. On the other hand, the urea and the carbamate derivatives showed modest to moderate antiangiogenic activities. In summary, some bicyclic aminopyridinols can provide a good platform for structural exploitation in future medicinal chemistry work.

Novel heteroaryl phosphonates as cardioprotective agents

The invention teaches compound of general formula: Wherein: R1 is selected from H and CH3, and R2 is selected from H and OH, or R1 and R2 together form an optionally substituted phenyl ring which is fused to the pyridine ring; and R3 is selected from H, CH3, CH2OH and R4 is selected from H, CH3, CH2OH, R5 is selected from H, phenyl, halogen-substituted phenyl and Wherein R6 and R7 are each independently selected from H, Na+, K+, alkyl and optionally substituted aryl, and X and Y are each independently selected from H, OH and F, or at least one of X and Y is an heteroatom and together with R3 forms a bridge with the proviso that R4 is and N-oxides thereof, and biologically acceptable salts thereof, related compounds, related pharmaceutical compositions, and methods for treating various disorders using such compositions.