5719-24-4Relevant academic research and scientific papers
Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors
Goto, Taiji,Shiina, Akiko,Yoshino, Toshiharu,Mizukami, Kiyoshi,Hirahara, Kazuki,Suzuki, Osamu,Sogawa, Yoshitaka,Takahashi, Tomoko,Mikkaichi, Tsuyoshi,Nakao, Naoki,Takahashi, Mizuki,Hasegawa, Masashi,Sasaki, Shigeki
supporting information, p. 3325 - 3328 (2013/06/27)
2-Phenyl-4-piperidinyl-6,7-dihydrothieno[3,4-d]pyrimidine derivative (2) was found to be a new PDE4 inhibitor with moderate PDE4B activity (IC 50 = 150 nM). A number of derivatives with a variety of 4-amino substituents and fused bicyclic pyrim
Generation and trapping of 5,6-dimethylenepyrimidin-4-ones in Diels-Alder and Michael additions
Tome, Augusto C.,Cavaleiro, Jose A. S.,Storr, Richard C.
, p. 1723 - 1734 (2007/10/03)
Pyrimidone fused sulfones 5-7 were obtained from the reaction of amidines with 3-methoxycarbonyl-4-oxotetrahydrothiophene followed by N-methylation and oxidation with mCPBA. On heating in solution at 150°C, extrusion of SO2 occurred to give the highly reactive 5,6-dimethylenepyrimidin-4-ones which were intercepted in situ in Diels-Alder reactions to give the adducts 24-28 and in conjugate addition reactions with thiol nucleophiles to give the thioethers 29 and 30.
