5719-13-1

Upstream product

• 5719-24-4 2-phenyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-ol 
• 2689-68-1 methyl 4-oxotetrahydrothiophene-3-carboxylate 
• 5719-24-4 2-phenyl-3H-5,7-dihydrothieno<3,4-d>pyrimidin-4-one 

Downstream Products

• 1436866-13-5 2-[1-(6,6-dioxo-2-phenyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)-4-piperidyl]acetic acid 
• 1436866-15-7 2-[4-(6,6-dioxo-2-phenyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl]acetic acid 
• 1436866-19-1 2-[4-[(6,6-dioxo-2-phenyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)amino]-1-piperidyl]acetic acid 
• 1436866-22-6 2-[3-[(6,6-dioxo-2-phenyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)amino]phenyl]acetic acid 
• 1436866-23-7 3-[4-[(6,6-dioxo-2-phenyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)amino]phenyl]propanoic acid 
• 1436866-12-4 ethyl 2-[1-(6,6-dioxo-2-phenyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)-4-piperidyl]acetate 
• 1436866-14-6 ethyl 2-[4-(6,6-dioxo-2-phenyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl]acetate 
• 1436866-16-8 tert-butyl 4-[(6,6-dioxo-2-phenyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)amino]piperidine-1-carboxylate 
• 1436866-17-9 6,6-dioxo-2-phenyl-N-(4-piperidyl)-5,7-dihydrothieno[3,4-d]pyrimidin-4-amine hydrochloride 
• 1436866-18-0 C₂₃H₃₀N₄O₄S 
• 1436866-09-9 2-[1-(2-phenyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)-4-piperidyl]acetic acid 
• 1436866-11-3 2-[4-[(2-phenyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)amino]phenyl]acetic acid 
• 1436866-08-8 ethyl 2-[1-(2-phenyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)-4-piperidyl]acetate 
• 1436866-10-2 ethyl 2-[4-[(2-phenyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)amino]phenyl]acetate 

Relevant academic research and scientific papers

Pyrimidine ortho-quinodimethanes

The pyrimidine sulfones 10, R = Me; Nu = OMe, NEt2, SPh, H and 11, R = Ph; Nu = OMe were synthesised from the dihydrothienopyrimidones 7, R = Me, Ph by conversion to the chloro derivatives 8 followed by oxidation with mCPBA and reaction with the appropriate nucleophile or hydrogen and Pd. Heating of the sulfones in 1,2,4-trichlorobenzene gave the pyrimidine o-quinodimethanes which were intercepted in Diels-Alder reactions to give tetrahydroquinazolines.

Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors

2-Phenyl-4-piperidinyl-6,7-dihydrothieno[3,4-d]pyrimidine derivative (2) was found to be a new PDE4 inhibitor with moderate PDE4B activity (IC 50 = 150 nM). A number of derivatives with a variety of 4-amino substituents and fused bicyclic pyrim