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(+-)-5,6-Dihydro-6-(2-thienyl)imidazo(2,1-b)thiazole is a heterocyclic organic compound with the molecular formula C?H?N?S?. It features a dihydroimidazothiazole core, which is a fused ring system consisting of an imidazole and a thiazole. The compound has a 2-thienyl group attached to the 6-position of the imidazothiazole, which introduces a sulfur-containing aromatic ring. This chemical is known for its potential applications in pharmaceuticals and agrochemicals, particularly as a building block for the synthesis of various biologically active molecules. Its chiral nature, indicated by the (+-) prefix, means that it exists as a mixture of both R and S enantiomers. The compound's properties, such as solubility and reactivity, can be influenced by the presence of the sulfur atoms and the aromatic thiophene ring, making it a subject of interest in the field of organic chemistry and drug design.

5719-88-0

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5719-88-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 5719-88-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,7,1 and 9 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 5719-88:
(6*5)+(5*7)+(4*1)+(3*9)+(2*8)+(1*8)=120
120 % 10 = 0
So 5719-88-0 is a valid CAS Registry Number.

5719-88-0Downstream Products

5719-88-0Relevant academic research and scientific papers

Synthesis and evaluation of thiophenyl derivatives as inhibitors of alkaline phosphatase

Chang, Lei,Duy, Do Le,Mébarek, Saida,Popowycz, Florence,Pellet-Rostaing, Stéphane,Lemaire, Marc,Buchet, René

, p. 2297 - 2301 (2011)

Pathological calcifications induced by deposition of basic phosphate crystals or hydroxyapatite (HA) on soft tissues are a large family of diseases comprising of ankylosing spondylitis (AS), end-stage osteoarthritis (OA) and vascular calcification. High activity of tissue non-specific alkaline phosphatase (TNAP) is a hallmark of pathological calcifications induced by HA deposition. The use of TNAP inhibitor is a possible therapeutic option to address calcific diseases produced by HA deposition on soft tissues. We report the synthesis of a series of thiopheno-imidazo[2,1-b]thiazole derivatives which were evaluated as potential inhibitors of TNAP displaying a large range of IC50 at pH 10.4 (from 42 ± 13 μM to more than 800 μM).

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