57197-12-3

Upstream product

• 67-56-1 methanol 
• 576-26-1 2.6-dimethylphenol 
• 654-42-2 1,4-dihydroxy-2,6-dimethylbenzene 
• 2431-91-6 4-methoxy-2,6-dimethylphenol 

Downstream Products

• 1027594-94-0 4,4-Dimethoxy-2,6-dimethyl-1-((R)-toluene-4-sulfinylmethyl)-cyclohexa-2,5-dienol 
• 127718-78-9 2-(2,2-Dimethoxy-4,6-dimethyl-5-oxo-cyclohex-3-enyl)-malononitrile 

Relevant academic research and scientific papers

Bromide-assisted oxidation of substituted phenols with hydrogen peroxide to the corresponding p-quinol and p-quinol ethers over WO4 2--exchanged layered double hydroxides

A simple and efficient one-pot synthesis of p-quinols and their ethers occurs over tungstate-exchanged layered double hydroxides (WO4 2--LDHs), which catalyze the bromide-assisted oxidation of substituted phenols to the corresponding 4-alkoxy- and 4-hydroxycyclohexa-2,5- dienones in high yields (see scheme).

Synthesis of polysubstituted bicyclo[3.3.1]nonane-3,7-diones from cyclohexa-2,5-dienones and dimethyl 1,3-acetonedicarboxylate

Oxidation of polysubstituted phenols with phenyliodonium diacetate gives cyclohexa-2,5-dienones, which on reaction with dimethyl 1,3-acetonedicarboxylate afford double-Michael-addition derivatives, whose hydrolysis and decarboxylation provides polysubstituted bicyclo[3.3.1]nonane-3,7-diones. For steric and/or electronic reasons, the Michael reaction only works with 3,5-unsubstituted or 3-substituted cyclohexa-2,5-dienones, if the substituent is not an electron-releasing or a good electron-withdrawing group. Hydrolysis and decarboxylation of the double-Michael adducts from 2,4,4- or 2,4,4,6-substituted cyclohexa-2,5-dienones gives only products of partial hydrolysis and decarboxylation, which exist exclusively in the enol form. (C) 2000 Elsevier Science Ltd.

π-Facial Diastereoselection in Diels-Alder Reactions of (R)-4-[(p-Tolylsulfinyl)methyl]quinols

Diels-Alder reactions of a range of (R)-4-hydroxy-4-[(p-tolylsulfinyl)methyl]-2,5-cyclohexadienones with cyclopentadiene and 1,3-pentadiene proceed in a total π-facial diastereoselective manner from the C-4 OH side. Ab initio calculations at the RHF/6-31G

A novel stereoselective synthesis of the ring AB podocarpate system

A new way of stereoselectively synthesizing rings A and B of podocarpate has been developed; the correct stereochemistry at C4 is obtained during a cyclization linking C2 to C3.