57198-82-0

Upstream product

• 68-35-9 sulfadiazine 

Downstream Products

• 124435-12-7 4-[1-(Naphthalene-2-carbonyl)-2-oxo-propylazo]-N-pyrimidin-2-yl-benzenesulfonamide 
• 113232-98-7 1-Methyl-3-(2',4',6'-trimethoxyphenyl)-2-(N¹-pyrimidin-2'''-yl-p-sulphamylbenzeneazo)propan-1,3-dione 
• 124435-20-7 4-(3-Methyl-5-naphthalen-2-yl-1-p-tolyl-1H-pyrazol-4-ylazo)-N-pyrimidin-2-yl-benzenesulfonamide 
• 145664-20-6 3-Oxo-2-{[4-(pyrimidin-2-ylsulfamoyl)-phenyl]-hydrazono}-hexanoic acid ethyl ester 
• 1046073-60-2 C₂₀H₁₆N₆O₆S₂ 
• 1046073-68-0 C₃₀H₂₃N₁₁O₈S₃ 
• 49752-95-6 ethyl 3-oxo-2-(2-{4-[N-(pyrimidin-2-yl)sulfamoyl]phenyl}hydrazono)butanoate 
• 124435-26-3 4-[3-Methyl-5-naphthalen-2-yl-1-(1,3,3-trimethyl-bicyclo[2.2.1]hept-2-yl)-1H-pyrazol-4-ylazo]-N-pyrimidin-2-yl-benzenesulfonamide 
• 145664-38-6 4-{N'-[5-Oxo-1-(1-oxy-pyridine-3-carbonyl)-3-propyl-1,5-dihydro-pyrazol-(4Z)-ylidene]-hydrazino}-N-pyrimidin-2-yl-benzenesulfonamide 
• 145664-30-8 4-{N'-[5-Oxo-3-propyl-1-(pyridine-3-carbonyl)-1,5-dihydro-pyrazol-(4Z)-ylidene]-hydrazino}-N-pyrimidin-2-yl-benzenesulfonamide 

Relevant academic research and scientific papers

New approach for determination of sulfadiazine in pharmaceutical preparations using 4(4-sulphophenylazo)pyrogallol: Kinetic spectrophotometric method

A new trend describes the development and validation of a simple, sensitive and selective kinetic spectrophotometric methods for the determination of sulfadiazine in pharmaceutical formulations has been conducted. In this paper, sulfadiazine was derivatiz

Synthesis, in vitro and in Silico studies of some novel 5-nitrofuran-2-yl hydrazones as antimicrobial and antitubercular agents

In this study, we synthesized two series of novel 5-nitrofuran-2-carbohydrazides 21a-h and 22a-e in addition to a third series of thiophene-2-carbohydrazides 23a-g to develop potent antimicrobial and/or antitubercular agents. The newly synthesized compounds were evaluated in vitro for their antimicrobial and antimycobacterial activities. Most of the 5-nitrofuran-2-carbohydrazides 21a-h and 22a-e displayed variable activity against Aspergillus fumigates, Staphylococcus aureus, Streptococcus pneumonia, Bacillis subtilis, Salmonella typhimurium, Klebsiella pneumonia, Escherichia coli and Mycobacterium tuberculosis. The sulfonamide derivative 21f exhibited superior potency and broad-spectrum antimicrobial activity with minimum inhibitory concentration (MIC)=0.06-0.98 μg/mL and antimycobacterial activity with MIC=3.9 μg/mL. The 5-nitrofuran-2-carbohydrazides 21a, b, g, h and 22a-c exhibited significant antibacterial activity with MIC values in the range of 0.12-7.81 μg/mL. The significances of the 5-nitrofuran moiety and sulfonamide function were explored via the structure-activity relationship (SAR) study. In addition, docking studies revealed that the p-amino benzoic acid (PABA) and binding pockets of the dihydropteroate synthase (DHPS) were successfully occupied by compound 21f. Furthermore, two quantitative structure-activity relationship (QSAR) models were built to explore the structural requirements which controlled the activity.

Polymer complexes: XLXII-interplay of coordination π-π Stacking and hydrogen bonding in supramolecular assembly of [sulpha drug derivatives-N,S:N,O] complexes

A novel series of nickel(II) polymer complexes of 5-sulphadiazineazo-3- phenylamino-2-thio-4-thiazolidinone (HL1), 5-sulphamethazine-3- phenylamino-2-thioxo-4-thiazolidinone (HL2), 5-sulphamethoxazole-3- phenylamino-2-thioxo-4-thiazo

ANTIBACTERIAL ACID DYES AND METHOD OF PREPARING THE SAME AND ANTIBACTERIAL FIBER DYED THEREBY

Disclosed are antibacterial acid dyes comprising two identical sulfonamide based antibacterial compounds bonded to acidic dyes by diazotization-coupling reaction, the antibacterial compounds of which have strong antibacterial properties, and a method of p

Synthesis of some New Pyrazolin-5-ones

Synthesis of some sufonamoylhydrazonopyrazolin-5-ones have been reported.