49752-95-6

Upstream product

• 141-97-9 ethyl acetoacetate 
• 57198-82-0 4-(Pyrimidin-2-ylsulfamoyl)-benzenediazonium; chloride 
• 68-35-9 sulfadiazine 
• 1723-25-7 ethyl 2,3-dioxobutyrate 

Downstream Products

• 49753-07-3 4-{2-[1-(2,4-dinitrophenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene]hydrazinyl}-N-(pyrimidin-2-yl)benzenesulfonamide 
• 52605-77-3 4-{2-[3-methyl-5-oxo-1-phenyl-1H-pyrazol-4(5H)-ylidene]hydrazinyl}-N-(pyrimidin-2-yl)benzenesulfonamide 
• 52605-76-2 4-{2-[3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene]hydrazinyl}-N-(pyrimidin-2-yl)benzenesulfonamide 
• 95914-56-0 4-[(3-methyl-5-oxo-isoxazol-4-ylidene)-hydrazino]-N-pyrimidin-2-yl-benzenesulfonamide 

Relevant academic research and scientific papers

Pyrazole and Nicotinonitrile Derivatives Synthesized from Sulfa Drugs, and Their Antibacterial Activity

Utility of sulfadiazine and sulfaguanidine in synthesis of new series of pyrazoles and 2-pyridones is described. Diazotization of sulfadiazine that results in formation of diazonium salt 2 followed by coupling of the latter with active methylene compounds

Synthesis and antidiabetic evaluation of novel pyrazolone derivatives

Ethyl-2-[diazo(substituted benzene) acetoacetates (2a-h) were treated with benzhydrazide (3) to yield the title compounds pyrazolone derivatives (4a-h). All the new compounds were characterized by IR, 1H-NMR, Mass and elemental analysis. The title compounds were subjected to in-vitro antidiabetic activity by α-amylase and α-glucosidase inhibitory activity. Compounds 4b and 4c showed good antidiabetic activity when compared to the standard drug acarbose.

Synthesis of some New Pyrazolin-5-ones

Synthesis of some sufonamoylhydrazonopyrazolin-5-ones have been reported.