57248-88-1 Usage
Description
Disodium pamidronate is a calcium metabolism regulator useful in the treatment of
hypercalcemia associated with malignancy. It presumably reduces the bone resorption of
calcium by inhibiting the formation and attachment of osteoclasts. Other potential uses
include osteoporosis and calcitonin-resistant Paget’s disease.
Chemical Properties
White Crystals
Originator
Henkel (United Kingdom)
Uses
Different sources of media describe the Uses of 57248-88-1 differently. You can refer to the following data:
1. Pamidronate disodium is a nitrogen containing bisphosphonate, used to prevent osteoporosis. It is used to prevent bone loss, and treat osteoporosis.
2. A farnesyl diphosphate synthase inhibitor
Biochem/physiol Actions
Pamidronate disodium?has the ability to block Wnt and β-catenin signaling, which modulates the osteogenic differentiation in bone marrow mesenchymal stem cells (BMMSCs). It can also reduce bilirubin-impaired apoptosis and helps to develop dentinogenic dysfunction of stem cells from human deciduous teeth.
Veterinary Drugs and Treatments
Pamidronate may be useful in treating hypercalcemia associated
with vitamin D-related toxicoses or hypercalcemia of malignancy.
There is ongoing research on the use of this drug to determine if
it has clinical usefulness in directly treating “micro-metastases” in
osteosarcomas.
Check Digit Verification of cas no
The CAS Registry Mumber 57248-88-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,2,4 and 8 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 57248-88:
(7*5)+(6*7)+(5*2)+(4*4)+(3*8)+(2*8)+(1*8)=151
151 % 10 = 1
So 57248-88-1 is a valid CAS Registry Number.
InChI:InChI=1/C3H11NO7P2.2Na/c4-2-1-3(5,12(6,7)8)13(9,10)11;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;/q;2*+1/p-2
