57259-91-3

Basic information

• Product Name: 1-(3-benzo[1,3]dioxol-5-yl-acryloyl)-4-(4-oxo-5-phenyl-4,5-dihydro-oxazol-2-yl)-piperazine
• CAS NO: 57259-91-3
• Molecular Weight: 419.437
• Mol File: 57259-91-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3-benzo[1,3]dioxol-5-yl-acryloyl)-4-(4-oxo-5-phenyl-4,5-dihydro-oxazol-2-yl)-piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-benzo[1,3]dioxol-5-yl-acryloyl)-4-(4-oxo-5-phenyl-4,5-dihydro-oxazol-2-yl)-piperazine(57259-91-3)
• EPA Substance Registry System: 1-(3-benzo[1,3]dioxol-5-yl-acryloyl)-4-(4-oxo-5-phenyl-4,5-dihydro-oxazol-2-yl)-piperazine(57259-91-3)

Safety Data

• Hazardous Substances Data: 57259-91-3(Hazardous Substances Data)

Upstream product

• 2152-34-3 2-amino-5-phenyl-4-oxazolinone 
• 96249-87-5 3-benzo[1,3]dioxol-5-yl-acryloyl chloride 
• 14021-76-2 5-phenyl-2-piperazin-1-yl-oxazol-4-one 

Relevant articles and documents

Antimalarials. Synthesis and antimalarial activity of 1 (4 methoxycinnamoyl) 4 (5 phenyl 4 oxo 2 oxazolin 2 yl)piperazine and derivatives

The preparation and activity against Plasmodium berghei of derivatives of 1 (4 methoxycinnamoyl) 4 (5 phenyl 4 oxo 2 oxazolin 2 yl)piperazine are described. Replacement of the cinnamoyl group was accomplished by acylation or alkylation of 1 (5 phenyl 4 oxo 2 oxazolin 2 yl)piperazine. Modifications of the 5 phenyl group were prepared either by a sequence of reactions involving mandelic ester pemoline piperazine pemoline or by the reaction of 5 aryl 2 thio 2,4 oxazolidinedione with piperazine or N substituted piperazines. In a similar manner, pemoline was allowed to react with N arylpiperazine, hexahydro 1H 1,4 diazepine, and 2,6 dimethylpiperazine to provide N arylpiperazine pemoline derivatives and variations in the piperazine moiety. Several compounds in which the 2 oxazolin 4 one ring was replaced with other heterocyclic rings were prepared as were several open chain analogs. Five compounds (three of them substituted in the para position of the 5 phenyl group and two N arylpiperazine pemoline derivatives) were found to be active against Plasmodium berghei. The remaining active compound possessed changes in the cinnamoyl group and substitution on the 5 phenyl group.