57260-67-0

Basic information

• Product Name: 1-(3,4-Dichlorophenyl)piperazine
• Synonyms: Piperazine, 1-(3,4-dichlorophenyl)-;1-(3,4-DICHLOROPHENYL)PIPERAZINE;N-(3,4-DICHLOROPHENYL)PIPERAZINE;RARECHEM AH CK 0083;TIMTEC-BB SBB003275;1,2-Dichloro-4-(1-piperazino)benzene;1-(3,4-Dichlorophenyl)piperazine 98%;1-(3,4-DICHLOROPHENYL)-PIPERAZINE >98%
• CAS NO: 57260-67-0
• Molecular Formula: C₁₀H₁₂Cl₂N₂
• Molecular Weight: 231.12
• EINECS: 260-652-9
• Product Categories: PiperazineDerivative;Piperaizine;Piperazine derivates;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Piperazines;PiperazinesHeterocyclic Building Blocks
• Mol File: 57260-67-0.mol
• Article Data: 10

Chemical Properties

• Melting Point: 62-66 °C
• Boiling Point: 179 °C (15 mmHg)
• Flash Point: 202°C/15mm
• Appearance: pale yellow crystalline powder
• Density: 1.2949 (rough estimate)
• Vapor Pressure: 1.14E-05mmHg at 25°C
• Refractive Index: 1.6400 (estimate)
• Storage Temp.: Store below +30°C.
• PKA: 8.71±0.10(Predicted)
• BRN: 520169
• CAS DataBase Reference: 1-(3,4-Dichlorophenyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-Dichlorophenyl)piperazine(57260-67-0)
• EPA Substance Registry System: 1-(3,4-Dichlorophenyl)piperazine(57260-67-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-24/25-36
• RIDADR: 3259
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 57260-67-0(Hazardous Substances Data)

Usage

Chemical Properties

pale yellow crystalline powder

General Description

1-(3,4-Dichlorophenyl)piperazine is an N-substituted piperazine. Its freezing point and boiling point are 335.65K and 643.73K. Its density and refractive index at 25°C are 1.2949g/cm3 and 1.6400.

InChI:InChI=1/C10H12Cl2N2/c11-9-2-1-8(7-10(9)12)14-5-3-13-4-6-14/h1-2,7,13H,3-6H2/p+1

Upstream product

• 20555-91-3 3,4-dichloroiodobenzene 
• 319926-92-6 tert-butyl 4-(3,4-dichlorophenyl)piperazine-1-carboxylate 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 95-76-1 m,p-dichloroaniline 
• 110-85-0 piperazine 
• 18282-59-2 4-bromo-1,2-dichlorobenzene 

Downstream Products

• 57260-37-4 2-[4-(3,4-dichloro-phenyl)-piperazin-1-yl]-5-phenyl-oxazol-4-one 
• 57962-01-3 2-{2-[4-(3,4-dichloro-phenyl)-piperazin-1-yl]-ethyl}-quinoline 
• 78069-90-6 1-(3,4-Dichloro-phenyl)-4-(3-nitro-pyridin-4-yl)-piperazine 
• 901124-68-3 6-chloro-2-[4-(3,4-dichloro-phenyl)-piperazin-1-ylmethyl]-imidazo[1,2-b]pyridazine 
• 1061517-09-6 C₂₈H₂₆Cl₂N₄O₂ 
• 1429300-90-2 N-[{4-(3,4-dichlorophenyl)-piperazin-1-yl}-methyl]-3-ethyl-3-methyl-pyrrolidine-2,5-dione 
• 1429300-80-0 N-[{4-(3,4-dichlorophenyl)-piperazin-1-yl}-methyl]-3,3-diphenyl-pyrrolidine-2,5-dione 
• 1618668-21-5 7-(4-(4-(3,4-dichlorophenyl)piperazin-1-yl)-4-oxobutoxy)-4-methyl-2H-chromen-2-one 
• 1618668-09-9 7-(4-(4-(3,4-dichlorophenyl)piperazin-1-yl)-4-oxobutoxy)-2H-chromen-2-one 
• 1618668-25-9 7-(2-(4-(3,4-dichlorophenyl)piperazin-1-yl)-2-oxoethoxy)-2H-chromen-2-one 
• 1513872-15-5 2-(1-(4-(3,4-dichlorophenyl)piperazin-1-yl)ethyl)-1H-indole 

Relevant articles and documents

MONOACYLGLYCEROL LIPASE INHIBITORS

Provided are compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof: Also provided are compositions comprising compounds of formula (I). The compounds and compositions are also provided for use as medicaments, for example as medicaments useful in the treatment of a condition modulated by monoacylglycerol lipase (MAGL). Also provided are the use of compounds and compositions for the inhibition of monoacylglycerol lipase (MAGL).

Discovery of imidazole carboxamides as potent and selective CCK1R agonists

High-throughput screening revealed diaryl pyrazole 3 as a selective albeit modest cholecystokinin 1 receptor (CCK1R) agonist. SAR studies led to the discovery and optimization of a novel class of 1,2-diaryl imidazole carboxamides. Compound 44, which was profiled extensively, showed good in vivo mouse gallbladder emptying (mGBE) and lean mouse overnight food intake (ONFI) reduction activities.

Tetracyclic benzimidazole derivatives and combinatorial libraries thereof

The present invention relates to novel tetracyclic benzimidazole derivative compounds of the following formula: wherein R1to R10have the meanings described in here. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing tetracyclic benzimidazole derivative compounds.