5728-37-0Relevant articles and documents
A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066
De Fusco, Claudia,Brear, Paul,Iegre, Jessica,Georgiou, Kathy Hadje,Sore, Hannah F.,Hyv?nen, Marko,Spring, David R.
supporting information, p. 3471 - 3482 (2017/05/29)
Recently we reported the discovery of a potent and selective CK2α inhibitor CAM4066. This compound inhibits CK2 activity by exploiting a pocket located outside the ATP binding site (αD pocket). Here we describe in detail the journey that led to the discov
Silver-catalyzed arylation of (hetero)arenes by oxidative decarboxylation of aromatic carboxylic acids
Kan, Jian,Huang, Shijun,Lin, Jin,Zhang, Min,Su, Weiping
supporting information, p. 2199 - 2203 (2015/02/19)
A long-standing challenge in Minisci reactions is achieving the arylation of heteroarenes by oxidative decarboxylation of aromatic carboxylic acids. To address this challenge, the silver-catalyzed intermolecular Minisci reaction of aromatic carboxylic acids was developed. With an inexpensive silver salt as a catalyst, this new reaction enables a variety of aromatic carboxylic acids to undergo decarboxylative coupling with electron-deficient arenes or heteroarenes regardless of the position of the substituents on the aromatic carboxylic acid, thus eliminating the need for ortho-substituted aromatic carboxylic acids, which were a limitation of previously reported methods.