5728-43-8

Basic information

• Product Name: 3'-CHLORO-BIPHENYL-4-CARBOXYLIC ACID
• Synonyms: 3'-CHLORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID;3'-CHLORO-BIPHENYL-4-CARBOXYLIC ACID;4-BIPHENYL-3'-CHLORO-CARBOXYLIC ACID;AKOS BAR-0008;[1,1'-BIPHENYL]-4-CARBOXYLIC ACID, 3'-CHLORO-;RARECHEM AL BE 1341;4-(3-Chlorophenyl)benzoic acid;4-Carboxy-3'-chlorobiphenyl, 4-(3-Chlorophenyl)benzoic acid
• CAS NO: 5728-43-8
• Molecular Formula: C₁₃H₉ClO₂
• Molecular Weight: 232.66
• Product Categories: pharmacetical
• Mol File: 5728-43-8.mol
• Article Data: 13

Chemical Properties

• Melting Point: 254-255°C
• Boiling Point: 402.3 °C at 760 mmHg
• Flash Point: 197.1 °C
• Appearance: /
• Density: 1.298g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3'-CHLORO-BIPHENYL-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-CHLORO-BIPHENYL-4-CARBOXYLIC ACID(5728-43-8)
• EPA Substance Registry System: 3'-CHLORO-BIPHENYL-4-CARBOXYLIC ACID(5728-43-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 5728-43-8(Hazardous Substances Data)

Usage

General Description

3'-Chloro-biphenyl-4-carboxylic acid, also known as 3'-chloro-4-biphenylcarboxylic acid, is a chemical compound with the molecular formula C13H9ClO2. It is a chlorinated derivative of biphenyl carboxylic acid and is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and liquid crystals. It is a white to off-white solid at room temperature and is sparingly soluble in water but soluble in organic solvents like ethanol and acetone. 3'-CHLORO-BIPHENYL-4-CARBOXYLIC ACID is also known for its potential environmental and health impacts, as it is considered a hazardous substance and needs to be handled and disposed of with caution to prevent harm to humans and the environment.

Upstream product

• 2051-61-8 m-chlorobiphenyl 
• 63503-60-6 3-chlorophenylboronic acid 
• 74-11-3 para-chlorobenzoic acid 
• 586-76-5 4-Bromobenzoic acid 
• 1292307-43-7 triethylammonium tetra(3-chlorophenyl)borate 
• 5748-36-7 3'-chloro-[1,1'-biphenyl]-4-amine 
• 952-22-7 3‐chloro‐4′‐nitrobiphenyl 
• 5728-39-2 3'-Chlor-4-cyan-biphenyl 
• 5002-13-1 1-(3'-chlorobiphenyl-4-yl)ethanone 
• 89901-01-9 methyl 3'-chloro-[1,1'-biphenyl]-4-carboxylate 

Downstream Products

• 89901-01-9 methyl 3'-chloro-[1,1'-biphenyl]-4-carboxylate 

Relevant articles and documents

Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives

L-amino alcohol derivatives exhibited high antifungal activity, but the metabolic stability of human liver microsomes in vitro was poor, and the half-life of optimal compound 5 was less than 5 min. To improve the metabolic properties of the compounds, the scaffold hopping strategy was adopted and a series of antifungal compounds with a dihydrooxazole scaffold was designed and synthesized. Compounds A33-A38 substituted with 4-phenyl group on dihydrooxazole ring exhibited excellent antifungal activities against C. albicans, C. tropicalis and C. krusei, with MIC values in the range of 0.03–0.25 μg/mL. In addition, the metabolic stability of compounds A33 and A34 in human liver microsomes in vitro was improved significantly, with the half-life greater than 145 min and the half-life of 59.1 min, respectively. Moreover, pharmacokinetic studies in SD rats showed that A33 exhibited favourable pharmacokinetic properties, with a bioavailability of 77.69%, and half-life (intravenous administration) of 9.35 h, indicating that A33 is worthy of further study.

Preparation of triethylammonium tetra-arylborates (TEATABs): Coupling partners for the Suzuki reaction

(Chemical Equation Presented) Six triethylammonium tetra-arylborates (TEATABs) were synthesized via a convenient reproducible procedure and characterized by spectroscopic methods (1H, 13C, 11B NMR and electrospray ionization-high-resolution mass spectrometry). The compounds could be stored at ambient temperature and were useful as reactants in the Suzuki reaction in aqueous conditions when using commercially available catalysts. Copyright Taylor & Francis Group, LLC.

Discovery of new C3aR ligands. Part 1: Arginine derivatives

The synthesis and in vitro binding of several new arginine-containing C3aR ligands are reported. DMPK properties and functional activities of selected compounds have been evaluated. One compound is shown to be active in an in vivo model of airway inflamma