57290-99-0

Upstream product

• 57290-97-8 bischalcone 
• 103843-98-7 C₃₆H₃₄O₁₂ 
• 103843-99-8 1-{4,4'-Dihydroxy-2,6,2',6'-tetramethoxy-3'-[3-(4-methoxy-phenyl)-3-oxo-propionyl]-biphenyl-3-yl}-3-(4-methoxy-phenyl)-propane-1,3-dione 
• 123-11-5 4-methoxy-benzaldehyde 
• 57290-95-6 4,4'-dibenzyloxy-2,2'-,6,6'-tetramethoxybiphenyl 
• 57290-96-7 4,4'-dihydroxy-3,3'-diacetyl-2,2',6,6'-tetramethoxybiphenyl 

Relevant academic research and scientific papers

Biflavonoids as novel antituberculosis agents

A series of naturally occurring and synthetic biflavonoids was evaluated for inhibitory activity against Mycobacterium tuberculosis H37Rv (Mtb). Compounds 6, 24, and 25 demonstrated 96, 95, and 87% inhibition, respectively, at a screening concentration of 12.5 μg/mL. The type of linkage and the presence of methoxy- and nitro-substituents in biflavonoids may contribute to the observed inhibitory activity. The results of this study represent the discovery of biflavonoids as a potential new class of antituberculosis agent.

Synthesis of Biflavonoids. Part-I

Syntheses of the methyl ether derivatives of 6,6"-biapigenin (4), 6,6"-bisisoflavone (11), 6,6"-bisdihydroflavonol (12) and 5,5"-bisaurone (13) (all new compounds) were done by using 5,5'-linked dimer of 4,6-dimethyl ether of phloroacetophenone (2).The structures of these compounds were established on the basis of their spectral properties.