57294-86-7Relevant articles and documents
Regiospecific synthesis of 2-allylated-5-substituted tetrazoles via palladium-catalyzed reaction of nitriles, trimethylsilyl azide, and allyl acetates
Gyoung, Young Soo,Shim, Jae-Goo,Yamamoto, Yoshinori
, p. 4193 - 4196 (2000)
A variety of 2-allylated-5-substituted tetrazoles were prepared in excellent yields through the reaction of alkyl and arylidenemalononitriles, allyl acetates and trimethylsilyl azide in the presence of a palladium catalyst. (C) 2000 Elsevier Science Ltd.
Interrupted CuAAC-Thiolation for the Construction of 1,2,3-Triazole-Fused Eight-Membered Heterocycles from O-/N-Propargyl derived Benzyl Thiosulfonates with Organic Azides
Jannapu Reddy, Raju,Waheed, Md.,Haritha Kumari, Arram,Rama Krishna, Gamidi
supporting information, p. 319 - 325 (2021/12/02)
A copper(I)-catalyzed interrupted click-sulfenylation of O-/N-propargyl benzyl thiosulfonates with organic azides has been disclosed. The unified CuAAC-thiolation provides a wide range of triazole-fused eight-membered heterocycles in good to high (51–94%) yields under mild reaction conditions. Moreover, a three-component reaction is also achieved involving O-/N-propargyl benzyl thiosulfonates, benzyl bromide, and sodium azide to deliver fused-triazoles in 61–74% yields. From a synthetic point of view, the present protocol has been demonstrated at gram-scale reactions. A plausible mechanism is also proposed based on experimental results and control experiments. (Figure presented.).
Further investigation of harmicines as novel antiplasmodial agents: Synthesis, structure-activity relationship and insight into the mechanism of action
Marinovi?, Marina,Poje, Goran,Perkovi?, Ivana,Fontinha, Diana,Prudêncio, Miguel,Held, Jana,Pessanha de Carvalho, Lais,Tandari?, Tana,Vianello, Robert,Raji?, Zrinka
, (2021/07/19)
The rise of the resistance of the malaria parasite to the currently approved therapy urges the discovery and development of new efficient agents. Previously we have demonstrated that harmicines, hybrid compounds composed from β-carboline alkaloid harmine
Highly selective hydrosilylation of equilibrating allylic azides
Liu, Ruzhang,Liu, Yongmei,Wang, Juan,Wei, Zhen,Xue, Huaiguo
supporting information, p. 5038 - 5041 (2020/05/18)
The Pt-catalyzed hydrosilylation of equilibrating allylic azides is reported. The reaction provides only one out of four possible hydrosilylation products in good yields and with very high chemoselectivity (alk-1-enevs.alk-2-ene), regioselectivity (linearvs.branched), and excellent functional group tolerance.