573-32-0Relevant academic research and scientific papers
Design and Synthesis of Optically Pure Dibenzo-difuso-azacentrotriquinacene-based Pseudo-C2-Symmetric Cyclic Hydroxamic Acid
Ohtsuka, Naoya,Seki, Masato,Hoshino, Yujiro,Honda, Kiyoshi
supporting information, p. 1328 - 1331 (2019/10/22)
Cyclic hydroxamic acids are found in various natural products and bioactive compounds, which exhibit various bioactivities, such as HDAC inhibition and MMP inhibition. Furthermore, they have relatively high metal binding ability, therefore they can form v
Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. 1. 2-[2-(1-imidazolyl)alkyl]- 1(2H)-phthalazinones
Yamaguchi,Kamei,Koga,Akima,Kuroki,Ohi
, p. 4052 - 4060 (2007/10/02)
A number of 4-substituted 2-[ω-(1-imidazolyl)alkyl]-1(2H)-phthalazinones were synthesized in order to develop agents possessing both thromboxane A2 synthetase inhibitory and bronchodilatory activities. The pharmacological evaluation of these compounds disclosed that they have both activities to various extents. Both activities were slightly dependent on the length of the 2-substituents and largely affected by the nature of the 4-substituents. Compounds bearing phenyl and thienyl groups exhibited relatively high and well-rounded activities. Among these compounds, 12j and 15f were found to be the most effective agents having well-rounded activities in vitro and in vivo. Introduction of a carboxyl group reduced both activities contrary to our expectation. 4-(3-Pyridyl)phthalazinone 18b was of particular interest because of unexpectedly high in vivo activities in spite of an absence of significant in vitro activities.
STUDIES ON THE SYNTHESIS OF HETEROCYCLIC COMPOUNDS. XVII. THE PREPARATION OF MACROCYCLIC POLYESTER LIGANDS CONTAINING THE 2,2'-BIS(HYDROXYMETHYL)DIPHENYLMETHANE SUBCYCLIC UNIT
Corda, Luciana,Fadda, Anna Maria,Maccioni, Anna Maria,Maccioni, Antonio,Podda, Gianni
, p. 671 - 676 (2007/10/02)
Novel macrocyclic tetraester ligands containing the 2,2'-bid(hydroxymethyl)diphenylmethane subcyclic unit have been prepared using an intermediate dioxastannocin with diacyl chlorides.The products were characterized by analitycal and spectroscopic (IR and NMR) data.The MS spectra of these ligands have been studied and the fragmentation patterns and structures of the main ions are described.
