57302-79-1

Basic information

• Product Name: (2R,3S)-oxirane-2,3-diyldimethanol
• Synonyms: (2R,3S)-Oxirane-2,3-diyldimethanol; 2,3-oxiranedimethanol, (2R,3S)-; 2,3-Oxiranedimethanol, cis-
• CAS NO: 57302-79-1
• Molecular Formula: C₄H₈O₃
• Molecular Weight: 104.1045
• Mol File: 57302-79-1.mol
• Article Data: 13

Chemical Properties

• Melting Point: 57.5-58.5 °C
• Boiling Point: 236.2°C at 760 mmHg
• Flash Point: 96.7°C
• Density: 1.278g/cm³
• Vapor Pressure: 0.00867mmHg at 25°C
• Refractive Index: 1.483
• PKA: 14.14±0.10(Predicted)
• CAS DataBase Reference: (2R,3S)-oxirane-2,3-diyldimethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S)-oxirane-2,3-diyldimethanol(57302-79-1)
• EPA Substance Registry System: (2R,3S)-oxirane-2,3-diyldimethanol(57302-79-1)

Safety Data

• Hazardous Substances Data: 57302-79-1(Hazardous Substances Data)

Usage

General Description

(2R,3S)-oxirane-2,3-diyldimethanol is a chemical compound with a molecular formula of C4H8O3. It is also known as glycerol-1,2-carbonate and is commonly used in the synthesis of various organic compounds. (2R,3S)-oxirane-2,3-diyldimethanol is derived from glycerol and has two hydroxyl groups attached to the carbon atoms of the oxirane ring. It is primarily used as a building block in the production of polymers, resins, and other industrial chemicals. Additionally, it can also be used as a solvent for various chemical processes and as an intermediate in the pharmaceutical industry.

Upstream product

• 6117-80-2 1,4-butenediol 
• 821-11-4 trans-butene-1,4-diol 
• 821-11-4 1,4-butenediol 
• 109874-90-0 dimethyl (2S,3R)-2-bromo-3-hydroxysuccinate 

Downstream Products

• 6968-16-7 rac-threitol 
• 93367-10-3 (2S,3S)-3,4-epoxy-1,2-di-O-isopropylidenebutane-1,2-diol 
• 924898-89-5 (2S,3S)-3-O-benzyl-1,2-di-O-isopropylidene-5-hexene-1,2,3-triol 

Relevant articles and documents

Synthesis and Antifungal Activity of β -Hydroxysulfides of 1,3-Dioxepane Series

Synthesis of β-hydroxysulfides of 1,3-dioxepane series and their further functionalization were performed. Chiral β-hydroxysulfides were separated into enantiomers using enzymatic acylation by lipase PS. Study of antifungal activity of the obtained compou

Enzymatic resolution of syn-2-azido-1,3,4-trihydroxybutane catalysed by lipases in the transesterification mode

The enzymatic resolution of both syn-2-azido-1,3,4-trihydroxybutane 1 and syn-2-azido-1,4-diacetoxy-3-hydroxybutane 2 have been undertaken with different lipases as catalysts and vinyl acetate as acylating agent. Lipases Amano PS and Amano AK proved to be the superior catalysts for this resolution. Indeed, both enantiomers of 1 are easily available in good yields and very good e.e.s (up to >99%). The use of chiral HPLC with a Chiralcel OD- H column allowed the determination of e.e.s of both diacetate 2 and triacetate 3 (syn-2-azido-1,3,4-triacetoxybutane) in a single analysis and thus facilitated the precise control of the reaction. (C) 2000 Elsevier Science Ltd.

N-ARYL-SUBSTITUTED CYCLIC AMINE DERIVATIVE AND MEDICINE CONTAINING THE SAME AS ACTIVE INGREDIENT

The present invention provides an excellent squalene synthase inhibitor. Specifically, it provides a compound (I) represented by the following formula, a salt thereof or a hydrate of them. Wherein R1 represents an optionally substituted vinyl group or an aromatic ring which may be substituted; ???n is an integer of 0 to 2; ???X, Y and Z are the same as or different from each other and each represents an optionally substituted carbon atom, or an optionally substituted nitrogen a tom, sulfuratomoroxygenatom, and Y optionally represents a single bond, and when Y represents the single bond, the ring to which X, Y and Z belong is a 5-membered ring; ???CyA represents a 5- to 14 membered non-aromatic cyclic amino groupornon-aromatic cyclic amidogroupwhichmaybe substituted, and the non-aromatic cyclic amino group or the non-aromatic cyclic amido group optionally having an oxygen atom or a sulfur atom; ???W represents a chain expressed by(1) optionally substituted -CH2-CH2-,(2) optionally substituted -CH=CH-,(3) -C≡C-,(4) an optionally substituted phenylene group,(5) a single bond,(6) -NH-CO-,(7) -CO-NH-,(8) -NH-CH2-,(9) -CH2-NH-,(10) -CH2-CO-,(11) -CO-CH2-,(12) -O-(CH2)m-,(13) -(CH2)m-O- (where m represents an integer of 0 to 5),(14) -O-CH2-CR2=,(15) -O-CH2-CHR2- (where R2 represents a hydrogen atom, a C1-6 alkyl group or a halogen atom),(16) -NH-S(O)1-,(17) -S(O)1-NH-,(18) CH2-S(O)1-, or(19) -S(O)2-CH2- (where 1 represents 0, 1, or 2); and ???A represents a group having any of the following structural formulae: (wherein R3 and R4 represent independently a hydrogen atom or an optionally substituted C1-6 alkyl group, or combine through a carbon chain optionally containing a heteroatom to form a ring; ???R5 and R6 represent independently a hydrogen atom or an optionally substituted C1-6 alkyl group, or combine through a carbon chain optionally containing a heteroatom to form a ring; ???R7 represents a hydrogen atom, an optionally substituted C1-6 alkyl group, a hydroxyl group, an alkoxy group, a halogen atom or an optionally substituted amino group; ???R8 represents a hydrogen atom, a hydroxyl group, an alkoxy group, a halogen atom or an optionally substituted amino group; ???B1 represents an optionally substituted carbon atom, or an optionallysubstitutednitrogenatom, oxygen atom or sulfur atom; ???B2 represents an optionally substituted carbon atom or nitrogen atom; ???a and b represent an integer of 0 to 4, provided that a+b is an integer of 0 to 4; ???c represents 0 or 1; and----- represents a single bond or a double bond, provided that when c is 1 in which A is a quinuclidine having R8 represented by the case where R8 is a hydrogen atom or a hydroxyl group; Arl is an aromatic heterocycle; and W is one of (1) to (3), (6) to (11) and (16) to (19) are excluded).