821-11-4Relevant articles and documents
Electrolytic reduction of 2-butyne-1,4-diol as a route to trans-2-butene-1,4-diol
Pyatnitsyna,El'chaninov,Savost'yanov
, p. 2037 - 2038 (2006)
The effect of the cathode material on the electrochemical transformations of 2-butyne-1,4-diol at atmospheric pressure was studied by chromatographic analysis. The optimal parameters of the selective synthesis of trans-2-butene-1,4-diol were determined.
Design and synthesis of a nucleoside and a phosphonate analogue constructed on a branched-threo-tetrofuranose skeleton
Kiran,Wakamatsu, Hideaki,Natori, Yoshihiro,Takahata, Hiroki,Yoshimura, Yuichi
, p. 3949 - 3952 (2013)
The synthesis of a novel nucleoside phosphonate constructed on a branched-threo-tetrofuranose scaffold, as a potential antiviral agent, is described. The pseudosugar moiety served as the nucleoside skeleton was produced starting from 2-butyne-1,4-diol in
Stereochemistry-Controlled Mechanical Properties and Degradation in 3D-Printable Photosets
Becker, Matthew L.,Dove, Andrew P.,Khalfa, Anissa L.
supporting information, p. 17510 - 17516 (2021/11/04)
Stereochemistry provides an appealing handle by which to control the properties of small molecules and polymers. While it is established that stereochemistry in linear polymers affects their bulk mechanical properties, the application of this concept to photocurable networks could allow for resins that can accommodate the increasing demand for mechanically diverse materials without the need to significantly change their formulation. Herein, we exploit cis and trans stereochemistry in pre-resin oligomers to create photoset materials with mechanical properties and degradation rates that are controlled by their stereochemistry and molecular weight. Both the synthesis of stereopure (cis or trans) acrylate-terminated pre-polymers and the subsequent UV-triggered cross-linking occurred with a retention of stereochemistry, close to 100%. The stereochemistry of a 4 kDa oligomer within the resin enabled the tuning of the formulation to either a fast eroding, soft cis elastomer or a stiff trans plastic that is more resistant to degradation. These results demonstrate that stereochemistry is a powerful tool to modify the stiffness, toughness, and degradability of high-resolution, three-dimensional printed scaffolds from the same formulated ratio of components.
Continuous Flow Z-Stereoselective Olefin Metathesis: Development and Applications in the Synthesis of Pheromones and Macrocyclic Odorant Molecules**
Browne, Duncan L.,Colombel-Rouen, Sophie,Crévisy, Christophe,Curbet, Idriss,Mauduit, Marc,McBride, Tom,Morvan, Jennifer,Roisnel, Thierry
supporting information, p. 19685 - 19690 (2021/08/06)
The first continuous flow Z-selective olefin metathesis process is reported. Key to realizing this process was the adequate choice of stereoselective catalysts combined with the design of an appropriate continuous reactor setup. The designed continuous process permits various self-, cross- and macro-ring-closing-metathesis reactions, delivering products in high selectivity and short residence times. This technique is exemplified by direct application to the preparation of a range of pheromones and macrocyclic odorant molecules and culminates in a telescoped Z-selective cross-metathesis/ Dieckmann cyclisation sequence to access (Z)-Civetone, incorporating a serial array of continually stirred tank reactors.
Preparation method of N-(4-methylpyridine-3-yl) methyl carbamate
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Paragraph 0020; 0022; 0025; 0030; 0032; 0035; 0040; 0042, (2021/06/02)
The invention relates to the technical field of preparation methods of N-(4-methylpyridine-3-yl) methyl carbamate, and discloses preparation of potassium tert-butoxide and preparation of the potassium tert-butoxide by using potassium methoxide. According to the preparation method of the N-(4-methylpyridine-3-yl) methyl carbamate, a user uses the potassium methoxide to prepare the potassium tert-butoxide, so that the content of the potassium tert-butoxide is higher, the potassium tert-butoxide and the potassium methoxide are very similar in properties and functions, so that the cost is saved, the method for extracting a THT solvent by using 1, 4-dichlorobutene as a raw material is simple, and the method has the advantages that the use amount of the catalyst is small, the condition is mild, the extraction purity is high, so that the cost is reduced again; and the N-(4-methylpyridine-3-yl) methyl carbamate is obtained by catalyzing two high-purity raw materials through the catalyst carbonic acid diester and stirring, so that the preparation efficiency is improved, the purity of the prepared N-(4-methylpyridine-3-yl) methyl carbamate is improved, the over-high preparation cost of the N-(4-methylpyridine-3-yl) methyl carbamate is avoided, and the use of the user is facilitated.
