57320-01-1Relevant academic research and scientific papers
Utility of nitrogen nucleophiles: A simple route for the synthesis of 2-substituted benzimidazolylpyrimidines
Rao, S. Srinivas,Reddy, Ch.Venkata Ramana,Dubey, Pramod Kumar
, p. 380 - 386 (2015)
An efficient and simple route for the synthesis of 2-substituted benzimidazolylpyrimidines 5a-i has been developed from benzimidazolylunsaturated nitriles 2 using nitrogen nucleophiles. Treatment of 2 with thiourea/urea/guanidine hydrochloride in aq. KOH under reflux for 30 min gave 3, which on further alkylation with an alkylating agent under PTC conditions gave 5a-i. Alternatively 5a-i could also be prepared by treatment of 2 with an alkylating agent under PTC conditions followed by treatment with thiourea /urea/guanidine hydrochloride in aq. KOH for 30 min.
Reactions of cyanomethylbenzimidazoles. Part II. Reaction of cyanomethylbenzimidazoles with aldehydes methylketones and nitroso compounds.
Sawlewicz,Milczarska,Manowska
, p. 187 - 201 (2007/10/09)
Position of CH2CN group in the benzimidazole system determines the activity of hydrogen atoms of CH2 group in condensation reactions. Some of the obtained compounds show high tuberculostatic activity.
