57322-97-1

Upstream product

• 590-28-3 potassium cyanate 
• 108-86-1 bromobenzene 
• 100-60-7 N-methylcyclohexylamine 
• 591-50-4 iodobenzene 
• 199620-14-9 chromium⁽⁰⁾ hexacarbonyl 
• 19226-36-9 3-phenyl-5H-1,4,2-dioxazol-5-one 
• 103-71-9 phenyl isocyanate 
• 5329-14-6 aminosulfonic acid 
• 55-21-0 benzamide 
• 14579-95-4 N-(trimethylsilylmethyl)cyclohexylamine 
• 76681-39-5 1-cyclohexyl-3-phenyl-1-trimethylsilanylmethyl-urea 

Downstream Products

• 1783-33-1 N-Phenyl-N'-methyl-N'-cyclohexyl-formamidin 

Relevant academic research and scientific papers

2,2,2-Trifluroenthanol promoted synthesis of unsymmetrical ureas from dioxazolones and amines via tandem lossen rearrangement/condensation process

A 2,2,2-trifluroenthanol (TFE) promoted synthesis of unsymmetric ureas was described. This approach enabled the construction of a variety of ureas from the readily prepared and easy-to-handle dioxazolones and amines via tandem Lossen rearrangement/condensation process. The reaction featured mild conditions for the urea synthesis under metal-free conditions, which was successively applied in the scale-up synthesis of herbicides Monuro and Isoproturon.

Palladium-Catalyzed Synthesis of Symmetrical and Unsymmetrical Ureas Using Chromium Hexacarbonyl as a Convenient and Safe Alternative Carbonyl Source

Pd-catalyzed synthesis of urea derivatives from aryl iodides and different aliphatic and aromatic amines using sodium azide and chromium hexacarbonyl is described. In this process, carbonylation of aryl iodides, Curtius rearrangement of aroyl azides, and nucleophilic addition of amines sequentially occur to afford the products in good to excellent yields. This protocol is operationally simple and displays a broad substrates scope.

Urea anions: Simple, fast, and selective catalysts for ring-opening polymerizations

Aliphatic polyesters and polycarbonates are a class of biorenewable, biocompatible, and biodegradable materials. One of the most powerful methods for accessing these materials is the ring-opening polymerization (ROP) of cyclic monomers. Here we report that the deprotonation of ureas generates a class of versatile catalysts that are simultaneously fast and selective for the living ring-opening polymerization of several common monomers, including lactide, δ-valerolactone, ε-caprolactone, a cyclic carbonate, and a cyclic phosphoester. Spanning several orders of magnitude, the reactivities of several diaryl urea anions correlated to the electron-withdrawing substituents on the aryl rings. With the appropriate urea anions, the polymerizations reached high conversions (～90%) at room temperature within seconds (1-12 s), yielding polymers with narrow molecular weight distributions (Crossed D sign = 1.06 to 1.14). These versatile catalysts are simple to prepare, easy to use, and exhibit a range of activities that can be tuned for the optimal performance of a broad range of monomers. (Chemical Equation Presented).

Assembly of N,N-disubstituted-N′-arylureas via a copper-catalyzed one-pot three-component reaction of aryl bromides, potassium cyanate, and secondary amines

A three-component reaction of aryl bromides, potassium cyanate, and secondary amines takes place at 110 C in MeCN under the catalysis of Cu 2O and 2-(2,6-dimethylphenylamino)-2-oxoacetic acid potassium salt, giving N,N-disubstituted-N′-arylurea

Design, synthesis, and photodegradation of silicon-containing polyureas

Novel N-phenyl aromatic polyureas containing bis[(N,N′- diphenylureylene)methyl]silane units in the skeleton were designed as a new type of photodegradable polymer. These materials were successfully prepared in 88-93% yields by copolymerization of bis(ani

Process for the production of amines

Amines and substituted ureas are produced by reaction of carboxamides with hypochlorites in the presence of bromine, iodine, polymerization inhibitors, and/or haloamides and excess alkali metal hydroxide with or without the addition of primary or secondary amines. The products are perfumes and starting materials for the production of dyes, plant protection agents and perfumes.