57327-92-1

Usage

Uses

Used in Pharmaceutical Industry:
(-)-DihydroapovincaMinic Acid Ethyl Ester is used as a chiral modifier for enantioselective heterogeneous catalytic hydrogenations. This application is significant because it helps in the synthesis of enantiomerically pure compounds, which are essential in the development of drugs with improved efficacy and reduced side effects.
Used in Cardiovascular Applications:
(-)-DihydroapovincaMinic Acid Ethyl Ester is used as a vasodilator due to its structural similarity to Vinpocetine (V332500). As a vasodilator, it helps in improving blood flow to the brain and other vital organs, which can be beneficial for patients suffering from conditions like stroke, dementia, and other cognitive disorders.

Upstream product

• 77549-94-1 3β-apovincaminic acid ethyl ester 
• 42971-09-5 Vinpocetine 

Relevant academic research and scientific papers

(-)-Dihydro-apovincaminic acid ethyl ester, preparation and use as a chiral modifier in enantioselective heterogeneous catalytic hydrogenations

The preparation, characterisation and use of (-)-dihydro-apovincaminic acid ethyl ester as a chiral modifier in heterogeneous catalytic asymmetric hydrogenations is reported. The epimeric compositions were determined using NMR and HPLC methods and circular dichroism spectroscopy was used to detect the interaction between the chiral modifier and the substrate.

Eburnamenine derivatives, pharmaceutical compositions and methods employing them and processes for their preparation

The invention relates to the preparation of cis and trans stereoisomers of racemic and optically active eburnamenine derivatives of the general formula (Ia) STR1 or (Ib), STR2 wherein R1 stands for a C1-4 alkyl group; and R stands fo