57328-03-7Relevant academic research and scientific papers
Toward Continuous-Flow Synthesis of Biologically Interesting Pyrazole Derivatives
Das, Amrita,Ishitani, Haruro,Kobayashi, Shū
supporting information, p. 5127 - 5132 (2019/11/13)
A two-step continuous-flow synthesis of substituted pyrazole derivatives has been developed via the formation of vinylidene keto esters as key intermediates. Heterogeneous Ni2+-montmorillonite was found to be an efficient catalyst for orthoester condensation of 1,3-dicarbonyls under flow conditions. The intermediate reacted with methylhydrazine to afford pyrazole derivatives, for which suitable selection of a solvent played a key role in achieving high yields and excellent regioselectivities of the desired products. An application of this protocol has been demonstrated by the synthesis of a key intermediate for biologically active pyrazoles such as Bixafen. (Figure presented.).
Quinolones as HCV NS5B polymerase inhibitors
Kumar, Dange V.,Rai, Roopa,Brameld, Ken A.,Somoza, John R.,Rajagopalan, Ravi,Janc, James W.,Xia, Yu M.,Ton, Tony L.,Shaghafi, Michael B.,Hu, Huiyong,Lehoux, Isabelle,To, Nhat,Young, Wendy B.,Green, Michael J.
experimental part, p. 82 - 87 (2011/02/27)
Hepatitis C virus (HCV) infection is treated with a combination of peginterferon alfa-2a/b and ribavirin. To address the limitations of this therapy, numerous small molecule agents are in development, which act by directly affecting key steps in the viral
