107259-14-3

Upstream product

• 5733-86-8 1-benzyl-5-oxopyrrolidine-3-carboxylic acid 
• 2414-98-4 magnesium ethylate 
• 105-53-3 diethyl malonate 
• 1026820-45-0 2-(1-Benzyl-5-oxo-pyrrolidine-3-carbonyl)-malonic acid diethyl ester 
• 127070-12-6 4-(2-Benzenesulfonyl-acetyl)-1-benzyl-pyrrolidin-2-one 

Downstream Products

• 163658-96-6 1-benzyl-4-(S)-<1-(S)-ethyl>-2-pyrrolidone 
• 163659-22-1 1-benzyl-4-(R)-<1-(S)-ethyl>-2-pyrrolidone 
• 163658-94-4 1-benzyl-4-(S)-<1-(R)-ethyl>-2-pyrrolidone 
• 163658-95-5 1-benzyl-4-(R)-<1-(R)-ethyl>-2-pyrrolidone 
• 163659-01-6 1-benzyl-3-(S)-(1-(S)-tert-butoxycarbonylaminoethyl)pyrrolidine 
• 163659-24-3 1-benzyl-3-(R)-(1-(S)-tert-butoxycarbonylaminoethyl)pyrrolidine 
• 156856-25-6 1-benzyl-3-(S)-(1-(R)-tert-butoxycarbonylaminoethyl)pyrrolidine 
• 163659-00-5 1-benzyl-3-(R)-(1-(R)-tert-butoxycarbonylaminoethyl)pyrrolidine 
• 163658-97-7 4-(S)-(1-(R)-aminoethyl)-1-benzyl-2-pyrrolidone 
• 163658-99-9 4-(S)-(1-(S)-aminoethyl)-1-benzyl-2-pyrrolidone 
• 163658-98-8 4-(R)-(1-(R)-aminoethyl)-1-benzyl-2-pyrrolidone 
• 163659-23-2 4-(R)-(1-(S)-aminoethyl)-1-benzyl-2-pyrrolidone 
• 117934-67-5 4-(1-aminoethyl)-1-benzyl-2-pyrrolidone 
• 156856-24-5 (R)-1-((S)-1-Benzyl-pyrrolidin-3-yl)-ethylamine 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of 7-[3-(1- aminoalkyl)pyrrolidinyl]- and 7-[3-1-aminocycloalkyl)pyrrolidinyl]-quinolone antibacterials

A series of 7-[3-(1-aminoalkyl and 1-aminocycloalkyl)-1- pyrrolidinyl]quinolones have been prepared and their biological properties evaluated. Among them, 1-(S)-aminoalkyl derivatives exhibited potent antibacterial activities against gram-positive and gram-negative organisms. They had moderate lipophilicity and high aqueous solubility compared to their aminomethyl counterparts; e.g., the 3-(1-aminoethyl)-1-pyrrolidinyl compound (83) showed superior pharmacokinetic properties to its aminomethyl counterpart (6).

Pyridonecarboxylic acid derivatives

This invention provides novel pyridonecarboxylic acid derivatives having a quite high antimicrobial activity. The derivatives have the following formula: STR1 wherein R1, R2 and R3 represent each a hydrogen or C1 -C6 alkyl group; R4 represents an ethyl, 2-fluoroethyl, vinyl, isopropyl, isopropenyl or cyclopropyl group; and X represents CH, C-F, C-Cl or N wherein (i) one of R1, R2 and R3 represents a hydrogen or C1 -C6 alkyl group, and (ii) either R1 forms a methylene chain having 2 to 4 carbon atoms together with R2 or R3, or R2 and R3 form together an alkylene chain having 2 to 5 atoms and R4 represents an ethyl, 2-fluorethyl, vinyl, isopropyl, isopropenyl or cyclopropyl group and X represents CH, C-F, or C-Cl and salt thereof.

AN EFFICIENT NEW METHOD FOR THE DESULFONYLATION OF β-KETO PHENYLSULFONES

β-Keto phenylsulfones can be readily desulfonylated with excess tri-n-butylstannane and AIBN, when heated at reflux in toluene, to provide the corresponding ketones in good-to-excellent yields.The reaction proceeds under neutral conditions and is compatible with a wide variety of functionalities.