57331-04-1

Basic information

• Product Name: Pregn-5-en-3-ol,20-methyl-21-[(3R)-3- methyl-2-(1-methylethyl)-1-cyclopropen-1- yl]-,(3â,20R)-
• CAS NO: 57331-04-1
• Molecular Weight: 410.684
• Mol File: 57331-04-1.mol

Chemical Properties

• CAS DataBase Reference: Pregn-5-en-3-ol,20-methyl-21-[(3R)-3- methyl-2-(1-methylethyl)-1-cyclopropen-1- yl]-,(3â,20R)- (CAS DataBase Reference)
• NIST Chemistry Reference: Pregn-5-en-3-ol,20-methyl-21-[(3R)-3- methyl-2-(1-methylethyl)-1-cyclopropen-1- yl]-,(3â,20R)- (57331-04-1)
• EPA Substance Registry System: Pregn-5-en-3-ol,20-methyl-21-[(3R)-3- methyl-2-(1-methylethyl)-1-cyclopropen-1- yl]-,(3â,20R)- (57331-04-1)

Safety Data

• Hazardous Substances Data: 57331-04-1(Hazardous Substances Data)

Upstream product

• 83511-84-6 (23R)-23,28-cyclostigmasta-5,24(28)-dien-3-β-ol 

Downstream Products

• 63015-89-4 26,27-dinorcholest-5-en-23-yn-3β-ol 
• 63015-91-8 cholesta-5-ene-23-yne-3β-ol 
• 85798-18-1 (28S)-calysterol 
• 85798-17-0 (24R)-24H-isocalysterol 
• 1042-59-7 20-methylpregn-5-en-3β-ol 
• 83-45-4 Stigmastanol 
• 55529-51-6 stigmastanol 
• 83542-22-7 24-methyl-24-homocholestanol 
• 83542-23-8 24-methyl-24-homocholestanol 

Relevant articles and documents

ACID-CATALYZED AND PHOTOCHEMICAL ISOMERIZATION OF STEROIDAL CYCLOPROPENES.

The acid-catalyzed and photochemical isomerization of two naturally occurring steroidal cyclopropenes, (28R)-calysterol and (23R)-23H-isocalysterol is described. Cyclopropene on treatment with methanolic sulfuric acid afforded 23-ethylated cholesterol derivatives containing conjugated diene systems or methoxylated side chains. The sole production of C-23 ethylated sterols demonstrates that this cyclopropene undergoes acid-promoted bond cleavage only between C-24 and C-28. By contrast, methanolic sulfuric acid treatment of the isomeric cyclopropene generated conjugated dienes with 24-methyl-24-homocholestane and 24-ethylcholestane side chains, together with their methoxylated derivatives. This implies that bond fission between C-23 and C-24, as well as C-23 and C-28, is operating in this instance, which is of mechanistic significance.