57334-32-4

Upstream product

• 108-95-2 phenol 
• 6180-61-6 3-phenoxypropanol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1610943-10-6 C₁₄H₁₉N₂O⁽¹⁺⁾*C₇H₇O₃S^(1-) 
• 1610943-55-9 C₁₄H₁₈IN₂O⁽¹⁺⁾*C₇H₇O₃S^(1-) 
• 93087-35-5 4-iodobenzoic acid phenyl ester 
• 93-99-2 benzoic acid phenyl ester 
• 36081-10-4 phenyl 3,4-dimethoxybenzoate 
• 588-63-6 3-phenoxypropyl bromide 

Relevant academic research and scientific papers

Preparation method of high-purity 3-phenoxypropyl bromide

The invention discloses a preparation method of aclidinium bromide key intermediate 3-phenoxypropyl bromide (formula I). The method comprises the following steps: by taking phenol and halogenated propanol as raw materials, carrying out nucleophilic substitution reaction under an alkaline condition to generate 3-phenoxy propanol, then reacting with a sulfonic acid esterification reagent to generateactive ester of 3-phenoxy propanol, refining the ester, and then reacting with a bromide of an alkali metal to generate 3-phenoxypropyl bromide. The preparation method provided by the invention has the advantages of cheap and easily available raw materials, simple operation, mild reaction conditions, no harsh reaction conditions, and high yield and purity of the obtained product, and is suitablefor industrial production.

Synthesis of ionic-liquid-supported diaryliodonium salts

The synthesis of ionic-liquid-supported diaryliodonium salts is described. The synthesis is simple and practical, and the ionic liquid products require no chromatographic purification. The ionic-liquid-supported diaryliodonium salts are quite stable, and they did not show any sign of decomposition or loss of reactivity, even after being stored for one month at 5 °C. The reactivity of these salts was explored in the phenylation of substituted phenols and carboxylic acids, and the corresponding diaryl ethers and aryl esters, respectively, were synthesized in good to excellent yields and with high purities.