57337-93-6

Upstream product

• 122-04-3 4-nitro-benzoyl chloride 
• 109-77-3 malononitrile 
• 5515-11-7 2-[hydroxy(4-nitrophenyl)methylene]malononitrile 
• 57338-04-2 2-[Hydroxy-(4-nitro-phenyl)-methylene]-malononitrile; compound with triethyl-amine 

Downstream Products

• 57372-65-3 2-[(4-Cyano-phenylamino)-(4-nitro-phenyl)-methylene]-malononitrile 
• 605661-26-5 2-[amino(4-nitrophenyl)methylene]malononitrile 
• 439385-10-1 [(p-nitrophenylamino)-4-nitrophenylmethylidene]propanedinitrile 
• 605660-65-9 3-(4-nitrophenyl)isothiazolo[5,4-d]pyrimidin-4-amine 
• 605660-66-0 3-(4-aminophenyl)isothiazolo[5,4-d]pyrimidin-4-amine 
• 605661-27-6 (2Z)-3-amino-2-cyano-3-(4-nitrophenyl)prop-2-enethioamide 
• 605661-28-7 5-amino-3-(4-nitrophenyl)isothiazole-4-carbonitrile 
• 439385-16-7 [(p-aminophenylamino)-4-aminophenylmethylidene]propanedinitrile 
• 439385-19-0 [(m-aminophenylamino)-4-aminophenylmethylidene]propanedinitrile 
• 439385-13-4 [(m-nitrophenylamino)-4-nitrophenylmethylidene]propanedinitrile 
• 57338-01-9 2-[(4-Chloro-phenylamino)-(4-nitro-phenyl)-methylene]-malononitrile 

Relevant academic research and scientific papers

Isothiazolopyrimidines and isoxazolopyrimidines as novel multi-targeted inhibitors of receptor tyrosine kinases

A series of isothiazolopyrimidines and isoxazolopyrimidines were synthesized and identified as potent KDR inhibitors. SAR studies led to isothiazolopyrimidine urea analogs that potently inhibit VEGFR tyrosine kinases (KDR enzymatic and cellular IC50

Thiopyrimidine and isothiazolopyrimidine kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Thiopyrimidine and isothiazolopyrimidine kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compound, compositions containing the compounds, and methods of treatment using the compounds.

Thiopyrimidine and isothiazolopyrimidine kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.