57341-99-8Relevant academic research and scientific papers
Palladium-catalyzed copper-free sonogashira coupling reaction in water and acetone
Shi, Shengyin,Zhang, Yuhong
, p. 1843 - 1850 (2007)
An efficient palladium-catalyzed copper-free Sonogashira reaction in water and acetone has been developed under mild conditions. The results showed that the aryl iodides could carry out the cross-coupling reaction with a variety of terminal alkynes in high yields in water-acetone in the absence of amine, copper(I) salts, or phosphine ligands at 60°C for one hour, and good yields were obtained for aryl bromides at 60°C for 12-24 hours in the presence of triphenylphosphine and piperidine. The method could be used to synthesize polyethynyl aromatic compounds in a one-pot reaction. Georg Thieme Verlag Stuttgart.
A Sustainable, User-Friendly Protocol for the Pd-Free Sonogashira Coupling Reaction
Liori, Aggeliki A.,Stamatopoulos, Ioannis K.,Papastavrou, Argyro T.,Pinaka, Afroditi,Vougioukalakis, Georgios C.
, p. 6134 - 6139 (2018/09/06)
We herein present a new catalytic system for the palladium-free Sonogashira coupling reaction. The catalytically active moiety is formed in situ, in a straightforward and user-friendly manner, by combining a widely available low-cost copper salt and an N-
CLASS II HMG-COA REDUCTASE INHIBITORS AND METHODS OF USE
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Paragraph 0049, (2014/01/08)
Disclosed are compositions and methods for treating bacterial infections.
Palladium-catalyzed coupling reaction of terminal alkynes with aryl iodides in the presence of indium tribromide and its application to a one-pot synthesis of 2-phenylindole
Sakai, Norio,Annaka, Kimiyoshi,Konakahara, Takeo
, p. 1527 - 1530 (2007/10/03)
The use of a novel PdCl2(PPh3)2-InBr 3 reagent system to catalyze cross-coupling reactions of a variety of aryl iodides with several terminal alkynes is described. The corresponding functional alkyne derivatives were produced in good to excellent yields. Moreover, a catalytic amount of InBr3 effectively catalyzes the intramolecular cycloaddition of 2-phenylethynylaniline to form an indole skeleton in high yield.
