57342-29-7Relevant academic research and scientific papers
Synthesis of deuterated γ-linolenic acid and application for biological studies: Metabolic tuning and Raman imaging
Dodo, Kosuke,Sato, Ayato,Tamura, Yuki,Egoshi, Syusuke,Fujiwara, Koichi,Oonuma, Kana,Nakao, Shuhei,Terayama, Naoki,Sodeoka, Mikiko
, p. 2180 - 2183 (2021)
γ-Linolenic acid (GLA) is reported to show tumor-selective cytotoxicity through unidentified mechanisms. Here, to assess the involvement of oxidized metabolites of GLA, we synthesized several deuterated GLAs and evaluated their metabolism and cytotoxicity towards normal human fibroblast WI-38 cells and VA-13 tumor cells generated from WI-38 by transformation with SV40 virus. Deuteration of GLA suppressed both metabolism and cytotoxicity towards WI-38 cells and increased the selectivity for VA-13 cells. Fully deuterated GLA was visualized by Raman imaging, which indicated that GLA is accumulated in intracellular lipid droplets of VA-13 cells. Our results suggest the tumor-selective cytotoxicity is due to GLA itself, not its oxidized metabolites. This journal is
Synthesis of the ω6 (5z,8z)-tetradecadienoic and (7z,10z)-hexadecadienoic polyene fatty acids
Golovanov,Ganina,Groza,Eremin,Myagkova
, p. 26 - 30 (2015/05/27)
An approach using acetylenes was used and optimized to synthesize rare natural ω6 polyene fatty acids. The key synthetic step was cross-coupling of a propargyl derivative with a terminal acetylene in the presence of equimolar amounts of Cu(I).
