57354-92-4

Upstream product

• 5468-33-7 1-(4-chlorophenyl)-2-nitroethan-1-one 
• 698-16-8 benzohydroximoyl chloride 
• 112853-65-3 (4S,5S)-3-(4-Chloro-phenyl)-4-nitro-5-phenyl-4,5-dihydro-isoxazole 
• 28123-63-9 4-chlorobenzohydroximoyl chloride 
• 614-21-1 2-nitroacetophenone 
• 66687-39-6 1-(4-chloro-phenyl)-2-nitro-3-phenyl-propane-1,3-dione 1-oxime 
• 112853-65-3 (4S,5R)-3-(4-Chloro-phenyl)-4-nitro-5-phenyl-4,5-dihydro-isoxazole 

Downstream Products

• 57354-93-5 3-(4-chloro-phenyl)-5-phenyl-isoxazol-4-ylamine 

Relevant academic research and scientific papers

Trifluoromethylation of aromatic isoxazoles: Regio- and diastereoselective route to 5-trifluoromethyl-2-isoxazolines

It all adds up: The activation of aromatic isoxazoles with a nitro group at the 4-position has enabled the first regio- and diastereoselective trifluoromethylation at the 5-position of isoxazoles by nucleophilic addition using Me3SiCF3 (see scheme; DMF=N,N′- dimethylformamide). The process was demonstrated with a broad range of 3,5-aromatic, heteroaromatic and aliphatic substrates.

SYNTHESIS AND PROPERTIES OF AZOLES AND THEIR DERIVATIVES. PART XX. STUDIES ON THE THERMOLYSIS OF REGIO AND STEREOISOMERIC DIARYLNITRO-Δ2-ISOXAZOLINES

Thermolysis of stereoisomeric 3,5-diaryl-4-nitro-Δ2-isoxazolines 1, 3, depending on the applied solvent, leads to 3,5-diarylisoxazoles 4 or mixtures of 3,5-diarylisoxazoles 4 and 3,5-diaryl-4-nitroisoxazoles 6.Under similar conditions, 3,4-diar