57356-40-8

Basic information

• Product Name: BENZENEMETHANOL, 2-HYDROXY-4-NITRO-
• Synonyms: BENZENEMETHANOL, 2-HYDROXY-4-NITRO-;2-(Hydroxymethyl)-5-nitrophenol 95%;2-(Hydroxymethyl)-5-nitrophenol;2-Hydroxy-4-nitrobenzyl alcohol, 3-Hydroxy-4-(hydroxymethyl)nitrobenzene, (2-Hydroxy-4-nitrophenyl)methyl alcohol;2-Hydroxy-4-nitrobenzyl alcohol, 3-Hydroxy-4-(hydroxymethyl)nitrobenzene, (2-Hydroxy-4-nitrophenyl)methanol
• CAS NO: 57356-40-8
• Molecular Formula: C₇H₇NO₄
• Molecular Weight: 169.13478
• Mol File: 57356-40-8.mol
• Article Data: 11

Chemical Properties

• Melting Point: 145-149℃
• Boiling Point: 322.8°Cat760mmHg
• Flash Point: 147.5°C
• Appearance: /
• Density: 1.489g/cm³
• Vapor Pressure: 0.000145mmHg at 25°C
• Refractive Index: 1.644
• PKA: 8.27±0.19(Predicted)
• CAS DataBase Reference: BENZENEMETHANOL, 2-HYDROXY-4-NITRO-(CAS DataBase Reference)
• NIST Chemistry Reference: BENZENEMETHANOL, 2-HYDROXY-4-NITRO-(57356-40-8)
• EPA Substance Registry System: BENZENEMETHANOL, 2-HYDROXY-4-NITRO-(57356-40-8)

Safety Data

• Hazardous Substances Data: 57356-40-8(Hazardous Substances Data)

Usage

General Description

BenzeneMethanol, 2-hydroxy-4-nitro- is a chemical compound with the molecular formula C7H7NO3. It is a yellow crystalline powder that is soluble in water and ethanol. It is used in the manufacturing of pharmaceuticals, dyes, and other organic compounds. It is also known as 2-hydroxy-4-nitrobenzyl alcohol and is commonly used as a precursor in the synthesis of various organic compounds. Additionally, it has potential antioxidant and antimicrobial properties, making it a valuable compound in the field of medicine and healthcare. However, it is important to handle this chemical with caution as it can be harmful if ingested or inhaled.

InChI:InChI=1/C7H7NO4/c9-4-5-1-2-6(8(11)12)3-7(5)10/h1-3,9-10H,4H2

Upstream product

• 98590-42-2 acetic acid 2-bromomethyl-5-nitrophenyl ester 
• 54362-24-2 2-acetoxy-4-nitrotoluene 
• 619-19-2 2-hydroxy-4-nitrobenzoic acid 
• 353276-02-5 2-acetoxy-1-acetoxymethyl-4-nitro-benzene 

Downstream Products

• 619-19-2 2-hydroxy-4-nitrobenzoic acid 
• 17580-65-3 4-nitro-salicylaldoxime 
• 874676-70-7 (E)-3-[2-(2-methoxyethoxy)-4-nitrophenyl]acrylic acid methyl ester 
• 874676-60-5 C₁₂H₁₃NO₅ 

Relevant articles and documents

Intramolecular Povarov Reactions for the Synthesis of Chromenopyridine Fused 2-Pyridone Polyheterocycles Binding to α-Synuclein and Amyloid-β Fibrils

A BF3·OEt2 catalyzed intramolecular Povarov reaction was used to synthesize 15 chromenopyridine fused thiazolino-2-pyridone peptidomimetics. The reaction works with several O-alkylated salicylaldehydes and amino functionalized thiazolino-2-pyridones, to generate polyheterocycles with diverse substitution. The synthesized compounds were screened for their ability to bind α-synuclein and amyloid β fibrils in vitro. Analogues substituted with a nitro group bind to mature amyloid fibrils, and the activity moreover depends on the positioning of this functional group.

3. 4 - diphenyl - 4H - 1, 2, 4 - triazole derivative and its preparation method and application (by machine translation)

The invention discloses 3, 4 - diphenyl - 4H - 1, 2, 4 - triazole derivative and its preparation method and application. In particular, the invention relates to the formula (I) structure of 3, 4 - diphenyl - 4H - 1, 2, 4 - triazole derivatives, its stereoisomers or its pharmaceutically acceptable salt, formula (I) in the definition of each substituent is as defined in the specification. These structure of novel compound with heat shock protein HSP90 inhibitory activity, can be used for treating cancer, neurodegenerative diseases, inflammatory diseases, autoimmune diseases, ischemic brain injury and the like, it has broad application prospects. (by machine translation)

Copper-Catalyzed Preparation of 2-Aryl-3-cyanobenzofurans with Bright Blue Photoluminescence

Copper-catalyzed cascade synthesis of 2-aryl-3-cyanobenzofurans from o-hydroxybenzaldehydes and arylacetonitriles in the presence of copper acetate and sodium methoxide is reported. The synthesized 2-aryl-3-cyanobenzofurans emit bright blue under UV light with a quantum yield up to 88.9%. (Chemical Equation Presented).