57362-77-3

Usage

Uses

Used in Organic Synthesis:
4-IODO-3-NITRO-BENZOIC ACID ETHYL ESTER is used as a key intermediate in the synthesis of complex organic molecules, facilitating the creation of a wide range of chemical products.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 4-IODO-3-NITRO-BENZOIC ACID ETHYL ESTER is used as a precursor in the development of various drugs, contributing to the synthesis of active pharmaceutical ingredients.
Used in Agrochemical Production:
Similarly, in the agrochemical sector, 4-IODO-3-NITRO-BENZOIC ACID ETHYL ESTER is employed as an intermediate for the synthesis of different agrochemicals, including pesticides and herbicides, to enhance crop protection and yield.

Upstream product

• 64-17-5 ethanol 
• 35674-27-2 4-iodo-3-nitrobenzoic acid 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 76918-64-4 ethyl 4-amino-3-nitrobenzoate 
• 23239-88-5 benzocaine hydrochloride 
• 619-58-9 4-iodobenzoic acid 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 

Downstream Products

• 5785-70-6 4-ethoxycarbonyl-2-nitrophenylboronic acid 
• 101420-88-6 4-iodo-3-nitrobenzaldehyde 
• 612825-76-0 5-hydroxymethyl-2-iodonitrobenzene 
• 1219744-26-9 C₁₂H₁₃NO₄ 
• 1361925-34-9 N-benzylcarbazole-2-carboxamide 
• 51094-28-1 9H-carbazole-2-carboxylic acid 
• 149913-93-9 6-ethoxycarbonyl-2-phenylindole 

Relevant academic research and scientific papers

Preparation of Functionalized Diorganomagnesium Reagents in Toluene via Bromine or Iodine/Magnesium-Exchange Reactions

A wide range of polyfunctionalized di(hetero)aryl- and dialkenyl-magnesium reagents are prepared in toluene within 10 to 120 minutes between 78 C and 25 C via an I/Mg- or Br/Mg-exchange reaction using reagents of the general formula R2Mg (R = sBu, Mes). Highly sensitive functional groups, such as triazene or nitro, are tolerated in these exchange reactions, enabling the synthesis of various functionalized (hetero)arene and alkene derivatives after quenching with several electrophiles including allyl bromides, acyl chlorides, aldehydes, ketones, and aryl iodides.

RETINOID COMPOUND, PREPARATION METHOD THEREFOR, INTERMEDIATES THEREOF AND APPLICATION THEREOF

Disclosed are a retinoid compound, a preparation method therefor, intermediates thereof and an application thereof. The retinoid compound I of the present invention has a good tumor growth inhibition rate.

BENZAMIDE OR BENZAMINE COMPOUNDS USEFUL AS ANTICANCER AGENTS FOR THE TREATMENT OF HUMAN CANCERS

The described invention provides small molecule anti-cancer compounds for treating tumors that respond to cholesterol biosynthesis inhibition. The compounds selectively inhibit the cholesterol biosynthetic pathway in tumor-derived cancer cells, but do not

Combined study of anion recognition by a carbazole-based neutral tripodal receptor in a competitive environment

Anion recognition studies have been carried out on a series of neutral synthetic receptors in which carbazole-2-carboxamide has been used as building block. Different ligands which include one to three carbazole units in their structure have been prepared

Highly stereoselective 7-endo-trig /ring contraction cascade to construct pyrrolo[1,2- a ]quinoline derivatives

With the cooperation of Cram's phenonium ion, a novel cascade reaction was illustrated to construct pyrrolo[1,2-a]quinolines as a sole diastereoisomer in good to excellent yields. Preliminary mechanistic studies revealed that the γ-lactam ring and electron-rich arene are important driving forces for ring contraction.

NOVEL CC-1065 ANALOGS AND THEIR CONJUGATES

This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.

Synthesis of functionalized nitroarylmagnesium halides via an iodine-magnesium exchange

(Chemical Equation Presented) Various nitro-substituted aryl and heteroaryl iodides undergo an iodine-magnesium exchange reaction when treated with PhMgCl leading to nitro-containing magnesium organometallics. These Grignard reagents display an excellent stability at temperatures below -40°C and do not undergo electron-transfer reactions. They react as expected with various electrophiles.