573671-47-3Relevant articles and documents
Design and synthesis of the tumor-activated prodrug of dihydropyrimidine dehydrogenase (DPD) inhibitor, RO0094889 for combination therapy with capecitabine
Hattori, Kazuo,Kohchi, Yasunori,Oikawa, Nobuhiro,Suda, Hitomi,Ura, Masako,Ishikawa, Tohru,Miwa, Masanori,Endoh, Mika,Eda, Hiroyuki,Tanimura, Hiromi,Kawashima, Akira,Horii, Ikuo,Ishitsuka, Hideo,Shimma, Nobuo
, p. 867 - 872 (2007/10/03)
A series of tumor-activated prodrugs of the inhibitors of dihydropyrimidine dehydrogenase (DPD), an enzyme catabolizing 5-fluorouracil (5-FU: 4g), has been designed and synthesized. RO0094889 (11c) is a prodrug of 5-vinyluracil (4c), a known DPD inhibitor