216449-54-6

Basic information

• Product Name: 5-(3-benzyloxybenzyl)-2',3'-bis-O-(tert-butyldimethylsilyl)-5'-deoxycytidine
• Synonyms: 5-(3-benzyloxybenzyl)-2',3'-bis-O-(tert-butyldimethylsilyl)-5'-deoxycytidine
• CAS NO: 216449-54-6
• Molecular Weight: 651.994
• Mol File: 216449-54-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-(3-benzyloxybenzyl)-2',3'-bis-O-(tert-butyldimethylsilyl)-5'-deoxycytidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-benzyloxybenzyl)-2',3'-bis-O-(tert-butyldimethylsilyl)-5'-deoxycytidine(216449-54-6)
• EPA Substance Registry System: 5-(3-benzyloxybenzyl)-2',3'-bis-O-(tert-butyldimethylsilyl)-5'-deoxycytidine(216449-54-6)

Safety Data

• Hazardous Substances Data: 216449-54-6(Hazardous Substances Data)

Upstream product

• 573671-39-3 Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-[5-(3-benzyloxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-5-methyl-tetrahydro-furan-3-yl ester 
• 573671-44-0 5-(3-Benzyloxy-benzyl)-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-methyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione 
• 28495-80-9 5-(m-(benzyloxy)benzyl)acyclouridine 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 37076-71-4 5-deoxy-1,2,3-tri-O-acetyl-D-ribofuranose 
• 573671-47-3 5-(3-benzyloxy-benzyl)-1-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-methyl-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione 

Relevant articles and documents

Design and synthesis of the tumor-activated prodrug of dihydropyrimidine dehydrogenase (DPD) inhibitor, RO0094889 for combination therapy with capecitabine

A series of tumor-activated prodrugs of the inhibitors of dihydropyrimidine dehydrogenase (DPD), an enzyme catabolizing 5-fluorouracil (5-FU: 4g), has been designed and synthesized. RO0094889 (11c) is a prodrug of 5-vinyluracil (4c), a known DPD inhibitor