573672-19-2Relevant academic research and scientific papers
Synthesis and biological evaluation of unnatural canthine alkaloids
Lindsley, Craig W.,Bogusky, Michael J.,Leister, William H.,McClain, Ray T.,Robinson, Ronald G.,Barnett, Stanley F.,Defeo-Jones, Deborah,Ross III, Charles W.,Hartman, George D.
, p. 2779 - 2782 (2005)
Employing a 'one-pot' microwave-assisted protocol, unnatural canthine alkaloids with biological activities beyond the natural products have been prepared. This report describes unnatural canthine alkaloid analogs as selective, allosteric Akt kinase inhibitors.
A 'one pot' microwave-mediated synthesis of the basic canthine skeleton: Expedient access to unnatural β-carboline alkaloids
Lindsley, Craig W.,Wisnoski, David D.,Wang, Yi,Leister, William H.,Zhao, Zhijian
, p. 4495 - 4498 (2003)
In a 'one pot' microwave reaction, an acyl hydrazide-tethered indole underwent a 3-component condensation to form a triazine, followed by an inverse-electron demand Diels-Alder reaction and subsequent chelotropic expulsion of N2 to deliver novel, unnatural β-carboline alkaloids in good isolated yields.
