573680-95-2

Upstream product

• 78-84-2 isobutyraldehyde 
• 159951-03-8 C₆H₅C₁₀H₁₂SON 
• 122-78-1 phenylacetaldehyde 
• 50635-99-9 (+)-(S)-(N-methylphenylsulfonimidoyl)methyllithium 

Downstream Products

• 573681-06-8 (+)-(3S,4R,5Z)-2-methyl-6-[(S)-N-methyl-S-phenylsulfonimidoyl]-4-phenyl-5-hexen-3-yl carbamate 
• 573682-31-2 (+)-(4S,5R,6S)-4-(chloromethyl)-tetrahydro-6-(1-methylethyl)-5-phenyl-2H-1,3-oxazin-2-one 
• 159951-03-8 C₆H₅C₁₀H₁₂SON 
• 1193-82-4 (S)-methylphenylsulfoxide 

Relevant academic research and scientific papers

Asymmetric synthesis of disubstituted C-silylated homoallylic alcohols from lithiated allylic and vinylic sulfoximines

Lithiation, titanation and hydroxyalkylation of allylic N-methyl sulfoximines 1-4 gave with ≥95% de the anti-Z-configurated homoallylic alcohols 5-9. Lithiation of 6b and 8b with MeLi readily produced the lithiated vinylic sulfoximines (Z)-12 and (Z)-13, respectively. Ni-catalyzed substitution of (Z)-12 and (Z)-13 with PhLi and 1,5-silyl migration yielded with ≥98% de the disubstituted C-silylated homoallylic alcohols (Z)-14 and (Z)-15, respectively. (Z)-15 thus obtained from (Z)-13 had an ee-value of ≥98%.