5737-83-7

Usage

Uses

Used in Pharmaceutical Industry:
AKOS BAR-2394 is used as a reagent for the synthesis of terphenyl derivatives, which are known to support cell growth and inhibit apoptosis in neuronal and HL-60 cells. This application is particularly relevant in the development of treatments for neurological disorders and cancer.
Used in Biotechnology Industry:
In the biotechnology industry, AKOS BAR-2394 is utilized as a key component in the development of novel drug delivery systems. Its role in the synthesis of terphenyl derivatives allows for the creation of compounds that can enhance the delivery, bioavailability, and therapeutic outcomes of various drugs, particularly in the context of cancer treatment.
Used in Chemical Synthesis:
AKOS BAR-2394 is also employed in the chemical synthesis of various organic compounds, contributing to the development of new materials and products across different industries. Its versatility as a reagent makes it a valuable asset in the field of chemical research and development.

Upstream product

• 591-18-4 1-Bromo-3-iodobenzene 
• 2113-57-7 3-bromobiphenyl 
• 87199-17-5 4-formylphenylboronic acid, 
• 400749-87-3 3’-bromobiphenyl-4-ylcarbaldehyde 
• 89900-91-4 methyl 3-bromo[1,1'-biphenyl]-4-carboxylate 
• 5730-89-2 4-acetyl-3'-bromobiphenyl 

Downstream Products

• 89900-91-4 methyl 3-bromo[1,1'-biphenyl]-4-carboxylate 
• 5728-45-0 3'-cyano-[1,1'-biphenyl]-4-carboxylic acid 
• 566915-66-0 3-adamantan-1-yl-4-benzyloxy-[1,1';3',1'']terphenyl-4''-carboxylic acid 

Relevant academic research and scientific papers

Novel terphenyls and 3,5-diaryl isoxazole derivatives endowed with growth supporting and antiapoptotic properties

A new study on terphenyl and diaryl-isoxazole and -isoxazoline derivatives, maintaining a common 3-adamantyl-4-hydroxyphenyl moiety, has been conducted to find compounds with growth supporting and antiapoptotic properties. Unexpectedly, diphenyisoxazole derivatives bearing a nitro group replacing the carboxylic function have been found with the highest cell protective activity within the series, in complete and in serum-free conditions. Inhibition of apoptosis induced by daunorubicin has also been observed for the most active compound.

Studies on the apoptotic activity of natural and synthetic retinoids: Discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells

New terphenyl derivatives have been synthesized and tested for their effect on cell survival in serum-free cultures. These compounds protected HL60 cells from death and supported their growth with an activity higher than that of the natural 14-hydroxy-retro-retinol. Terphenyls 26 and 28 also possess antiapoptotic activity on neuronal cells, proving them as possible candidates for the treatment of neurodegenerative and ischemic diseases.

A convenient synthesis of unsymmetrically substituted terphenyls of biologically active stilbenes via a double Suzuki cross-coupling protocol

A double Suzuki cross-coupling protocol has been devised as a practical route to a variety of terphenyls. Good chemoselectivity was observed. Unsymmetrically substituted triphenylenes were also easily prepared.

The Effects of Substituents on the Rate of Saponification of Biphenyl-4-carboxylates

Second-order rate constants have been measured for the saponification of methyl 2'-, 3'-, and 4'-substituted biphenyl-4-carboxylates at several temperatures in 85percent (w/w) methanol-water and activation parameters have been calculated.The Hammett equation applies very well to the saponification of 3'- and 4'-substituted biphenyl-4-carboxylates with ?-constants evaluated by the FMMF method.The effect of 2'-substituents is understandable in terms of ?-electron steric effects.